Major Histocompatibility Complex I and II

Question 1

Features of Major Histocompatibility Complex

Answer 1

Encoded by HLA genes; present antigen fragments to T-cells and bind TCRs

Question 2

MHC-I loci

Answer 2

HLA-A; HLA-B; HLA-C

Question 3

MHC-I binds to…

Answer 3

TCR and CD8

Question 4

Structure of MHC-I

Answer 4

1 long chain and 1 short chain

Question 5

Cells that express MHC-I are…

Answer 5

all nucleated cells, APCs, platelets; not on RBCs

Question 6

Function of MHC-I

Answer 6

Present endogenously synthesized antigens (viral or cytosolic proteins) to CD8+ cytotoxic T cells

Question 7

Antigen loading MHC-I steps

Answer 7

Antigen peptides loaded onto MHC-I in RER after delivery via TAP

Question 8

MHC-I associated structures

Answer 8

beta-2 microglobulin

Question 9

MHC-II loci

Answer 9

HLA-DP, HLA-DQ, HLA-DR

Question 10

MHC-II bind to…

Answer 10

TCRs and CD4

Question 11

MHC-II structure

Answer 11

2 equal length chains

Question 12

Cells that express MHC-II are…

Answer 12

APCs

Question 13

Function of MHC-II

Answer 13

Present exogenously synthesized antigens (bacterial proteins) to CD4+ helper T-cells

Question 14

Antigen loading MHC-II steps

Answer 14

Antigen loaded following release of invariant chain in an acidified endosome

Question 15

MHC-II associated structures

Answer 15

Invariant chain