Flashcards in March 20 Test 1 Deck (18):
What is the MOA of Digoxin?
Inhibits Na/K ATPase---causes increased Ca--positive inotrophy
Also stimulates vagus nerve--reducing HR
-Allows for longer filling time
What is the MOA of Tacrolimus?
Inhibits Calcineurin--binds the FK506 binding protein--prevents IL-2 transcription
What is the MOA of Disulfiram?
Inhibits acetaldehyde dehydrogenase--causing accumulation of acetaldehyde--intermediate from ETOH to Acetate---this causes hangover symptoms
What are the 5 organisms that can cause reactive arthritis?
What portion of the large bowel is most susceptible to ischemia due to being a watershed area?
What portion of the lymph node is least developed in the contexts of Di-george syndrome?
Paracortex--lymph node compartment that housed T-cells
Mutations of tumor suppressor gene WT1 and WT2 on Chromosome ____ occurs with Wilms tumor.
What is deficient in Tay-Sachs disease and what substrate accumulates?
What is the molecular role of bcl-2 protein?
Antagonist of apoptotic cell death
Along with bcl-x they prevent the release of cytochrome C and stops binding of APAF-1 and activating of the caspase cascade
So when its up-regulated in follicular lymphoma then malignant transformation is promoted
Young pt presents with tendon xanthomas and major increase in serum LDL, and an uncle who died of MI at age 20. Dx?
Familial hypercholesterolemia IIa--Absent or defective LDL receptors
What hormonal changes are seen with menopause?
Increased FSH, LH and GnRH
-No negative feedback of estrogen
Before age 40 with these labs--primary ovarian insufficiency
What endocrine hormones used cAMP signaling pathway?
What estrogen is important during menopause and where is it produced?
Estrone--produced by adipocytes
What disease has Cafe-au-lait spots, Lisch nodules (pigmented iris hamartomas), cutaneous neurofibromas, optic gliomas and pheochromocytoma?
Neurofibromatosis type I--mutated NF1 tumor suppressor gene on ch. 17
What substrate is increased in the urine with lead poisoning?
d-aminolevulinic acid--only at very high lead levels
What do the fibrates activate in order to increase HDL?
Activated PPAR-a to induce HDL synthesis
Genetic male (46, XY) age 14 presents with recent masculinization of external genitalia, which was previously ambiguous. Testes are found to be present in the abdomen. Dx?
5a-reductase deficiency--testosterone cannot be turned into DHT which is responsible for formation of external gonads
Feminized genitalia with normal internal genitalia