Mature B Cell Lymphomas

Question 1

Mature B cell lymphoma clinical outcome determined by

Answer 1

stage of differentiation

Question 2

t(11,14)

Answer 2

mantle cell lymphoma

cyclin D1

Question 3

t(14,18)

Answer 3

follicular cell lymphoma

BCL2

Question 4

t(8,14)

Answer 4

Burkitt lymhpoma

proliferation

Question 5

who gets mature B cell lymphomas

Answer 5

50-60y

kids

Question 6

EBV association

Answer 6

burkitt lymphoma

Question 7

hepatitis C association

Answer 7

lymphoblastic lymphoma

Question 8

indolent disease survival

Answer 8

> 5y

Question 9

slowly aggressive survival

Answer 9

3y

Question 10

aggressive disease survival

Answer 10

curable

Question 11

most common mature B cell lymhpomas

Answer 11

large B cell lymphoma

follicular lymhpoma

Question 12

chronic lymphocytic leukemia

Answer 12

lymphocyte expansion in blood
basket cells
are healthy on presentation

Question 13

small lymphocytic lymphoma

Answer 13

lymph involvement

present with enlarged nodes

Question 14

CD19, 20, 22

Answer 14

B cell

Question 15

CD5

Answer 15

mantle origin

Question 16

CLL/SLL no somatic mutation prognosis

Answer 16

bad

Question 17

CLL/SLL somatic mutation prognosis

Answer 17

good

Question 18

CLL/SLL prognosis

Answer 18

7y

Question 19

Richter syndrome

Answer 19

transformation of SLL/CLL into large cell lymhphoma

Question 20

men >50y
healthy OR lymph node enlargement
CD5+
CD19, CD20, CD22 +

Answer 20

CLL/SLL

Question 21

60y M
lymph, blood, extra nodal
CD19, CD20, CD22
cyclin D1
t(11,14)
CD5+

Answer 21

MCL

Question 22

lymphomatous polyposis assocaition

Answer 22

MCL

Question 23

mature b cell lymphoma associated with females

Answer 23

follicular lymphoma

Question 24

55F, young men
CD19, 20, 22 +
CD10, BCL6 +
centrocytes/centroblasts
paratragecular aggregates
BCL2 +
t(14,18)

Answer 24

follicular lymphoma

Question 25

most common large cell lymphoma transformation

Answer 25

follicular lymphoma

Question 26

types that can transform to large cell lymhpoma

Answer 26

follicular lymphoma | CLL/SLL

Question 27

rapidly enlarging masses- GI, ovary, lung secondary or primary (EBV, immunocompromised) CD19, 20, 22 + germinal center OR activated blood B-cell types CD10 +-

Answer 27

diffuse large B cell lymphoma

Question 28

rituximab

Answer 28

anti CD20

Question 29

most agressive mature B cell lymphoma

Answer 29

burkitt lymphoma

Question 30

facial bone involvement

Answer 30

endemic burkitt lymphoma

Question 31

abdominal mass involvement

Answer 31

sporadic burkitt lymphoma

Question 32

young kid from africa with large mass on face that grows very fast

Answer 32

burkitt lymphoma

Question 33

prepubescent girl with breast development

Answer 33

burkitt lymphoma

Question 34

starry sky appearance

Answer 34

Burkett lymphoma

Question 35

``` CD10 BCL6 + CD19, CD20, CD22 + TdT neg KI67 index 100% t(8,14) ```

Answer 35

Burkitt lymphoma

Question 36

burkitt lymphoma prognosis

Answer 36

90% survival if caught early | need 2y disease free to be considered cured

Question 37

burkitt lymphoma treatment

Answer 37

short term chemo- always dividing cells

Question 38

``` 50y M hairy cells lymphocytes secreting monocyte inhibitors splenomegaly fried egg appearance of bone marrow with dry tap red pulp involvement 103, 25, 11c + cyclin D + TRAP + ```

Answer 38

hairy cell leukemia

Question 39

disease of memory B cells

Answer 39

hairy cell leukemia

Question 40

treatment hairy cell leukemia

Answer 40

purine nucleoside analog (deoxycoformycin)

Question 41

``` 63y M Waldenstrom macroglobulinemia hyper viscosity hepatitis C Rouleaux CD19, 20, 22 IgM ```

Answer 41

lymphoplasmacytic lymphoma

Question 42

Waldenstrom macroglobulinemia

Answer 42

bone marrow involvement with IgM spike in blood

Question 43

``` 70y M black hypercalcemia renal insufficiency anemia lytic bone lesions spike M component- IgG, IgA, IgD in serum or urine Mott cell with symptoms lytic lesions in flat bones ```

Answer 43

plasma cell myeloma

Question 44

``` 70y M black hypercalcemia renal insufficiency anemia lytic bone lesions spike M component- IgM (+/-) Mott cell without symptoms ```

Answer 44

monoclonal gammopathy of undetermined significance

Question 45

order a serum and urine test if you suspect

Answer 45

plasma cell myeloma

Question 46

plasma cell myeloma prognosis with kidney damage

Question 47

plasma cell myeloma with limited symptoms prognosis

Answer 47

several years

Question 48

CRAB

Answer 48

``` hyperCalcinemia renal insufficiency anemia lytic Bone lesions associated with plasma cell myeloma ```