Mature B Cell Lymphomas Flashcards Preview

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Flashcards in Mature B Cell Lymphomas Deck (48):
1

Mature B cell lymphoma clinical outcome determined by

stage of differentiation

2

t(11,14)

mantle cell lymphoma
cyclin D1

3

t(14,18)

follicular cell lymphoma
BCL2

4

t(8,14)

Burkitt lymhpoma
proliferation

5

who gets mature B cell lymphomas

50-60y
kids

6

EBV association

burkitt lymphoma

7

hepatitis C association

lymphoblastic lymphoma

8

indolent disease survival

>5y

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slowly aggressive survival

3y

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aggressive disease survival

curable

11

most common mature B cell lymhpomas

large B cell lymphoma
follicular lymhpoma

12

chronic lymphocytic leukemia

lymphocyte expansion in blood
basket cells
are healthy on presentation

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small lymphocytic lymphoma

lymph involvement
present with enlarged nodes

14

CD19, 20, 22

B cell

15

CD5

mantle origin

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CLL/SLL no somatic mutation prognosis

bad

17

CLL/SLL somatic mutation prognosis

good

18

CLL/SLL prognosis

7y

19

Richter syndrome

transformation of SLL/CLL into large cell lymhphoma

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men >50y
healthy OR lymph node enlargement
CD5+
CD19, CD20, CD22 +

CLL/SLL

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60y M
lymph, blood, extra nodal
CD19, CD20, CD22
cyclin D1
t(11,14)
CD5+

MCL

22

lymphomatous polyposis assocaition

MCL

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mature b cell lymphoma associated with females

follicular lymphoma

24

55F, young men
CD19, 20, 22 +
CD10, BCL6 +
centrocytes/centroblasts
paratragecular aggregates
BCL2 +
t(14,18)

follicular lymphoma

25

most common large cell lymphoma transformation

follicular lymphoma

26

types that can transform to large cell lymhpoma

follicular lymphoma
CLL/SLL

27

rapidly enlarging masses- GI, ovary, lung
secondary or primary (EBV, immunocompromised)
CD19, 20, 22 +
germinal center OR activated blood B-cell types
CD10 +-


diffuse large B cell lymphoma

28

rituximab

anti CD20

29

most agressive mature B cell lymphoma

burkitt lymphoma

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facial bone involvement

endemic burkitt lymphoma

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abdominal mass involvement

sporadic burkitt lymphoma

32

young kid from africa with large mass on face that grows very fast

burkitt lymphoma

33

prepubescent girl with breast development

burkitt lymphoma

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starry sky appearance

Burkett lymphoma

35

CD10 BCL6 +
CD19, CD20, CD22 +
TdT neg
KI67 index 100%
t(8,14)

Burkitt lymphoma

36

burkitt lymphoma prognosis

90% survival if caught early
need 2y disease free to be considered cured

37

burkitt lymphoma treatment

short term chemo- always dividing cells

38

50y M
hairy cells
lymphocytes secreting monocyte inhibitors
splenomegaly
fried egg appearance of bone marrow with dry tap
red pulp involvement
103, 25, 11c +
cyclin D +
TRAP +

hairy cell leukemia

39

disease of memory B cells

hairy cell leukemia

40

treatment hairy cell leukemia

purine nucleoside analog (deoxycoformycin)

41

63y M
Waldenstrom macroglobulinemia
hyper viscosity
hepatitis C
Rouleaux
CD19, 20, 22
IgM

lymphoplasmacytic lymphoma

42

Waldenstrom macroglobulinemia

bone marrow involvement with IgM spike in blood

43

70y M black
hypercalcemia
renal insufficiency
anemia
lytic bone lesions
spike M component- IgG, IgA, IgD in serum or urine
Mott cell
with symptoms
lytic lesions in flat bones

plasma cell myeloma

44

70y M black
hypercalcemia
renal insufficiency
anemia
lytic bone lesions
spike M component- IgM (+/-)
Mott cell
without symptoms

monoclonal gammopathy of undetermined significance

45

order a serum and urine test if you suspect

plasma cell myeloma

46

plasma cell myeloma prognosis with kidney damage

47

plasma cell myeloma with limited symptoms prognosis

several years

48

CRAB

hyperCalcinemia
renal insufficiency
anemia
lytic Bone lesions
associated with plasma cell myeloma