Mechanism of Action: New Way of Thinking - Protein Based Mechanism Flashcards Preview

Apex 4 - 5 Volatile Anesthetics II: Pharmacodynamics (11) > Mechanism of Action: New Way of Thinking - Protein Based Mechanism > Flashcards

Flashcards in Mechanism of Action: New Way of Thinking - Protein Based Mechanism Deck (38)
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1

The Modern theory of anesthetic action suggests inhaled anesthetics: (Select 2)

Study on!!!!

2

Our current understanding of anesthetic action highlights the enormous complexity involved.

Tell me about it!

3

General anesthesia is produced by membrane-bound protein interactions in the ----- and -----.

Brain and Spinal cord

4

General anesthesia is produced by membrane-bound protein interactions in the brain and spinal cord. Anesthetic potency is ----- selective 

 

Stereoselective

5

General anesthesia is produced by membrane-bound protein interactions in the brain and spinal cord. The stereoselectivity of anesthetic potency suggests a ----- binding site

Chiral

6

General anesthesia is produced by membrane-bound protein interactions in the brain and spinal cord. The stereoselectivity of anesthetic potency suggests a chiral binding site. In addition, they probably affect specific ----- of the cell membrane

"areas"

7

As a general rule, the volatile anesthetics stimulate ----- receptors

A. inhibitory receptors

B. stimulatory receptors

inhibitory receptors

8

As a general rule, the volatile anesthetics inhibit ----- receptors

A. inhibitory receptors

B. stimulatory receptors

stimulatory receptors

9

So if you know if a neurotransmitter is stimulatory or inhibitory, you can easily deduce how an anesthetic will affect it

True

10

Volatile anesthetics ----- GABA-A receptor

 

"stimulate"

11

Volatile anesthetics ----- Glycine channels

 

"stimulate"

12

Volatile anesthetics ----- Potassium channels

 

 

 

"stimulate"

13

Volatile anesthetics ----- NMDA receptors

 

"inhibit"

14

Volatile anesthetics ----- Nicotinic receptors

 

"inhibit"

15

Volatile anesthetics ----- Sodium channels

 

"inhibit"

16

Volatile anesthetics ----- Dendritic spine function and motility

 

 

 

"inhibit"

17

In the brain, the most important site of volatile anesthetic action is the ----- receptor

GABA-A receptor

18

The GABA-A receptor is a ligand-gated ----- channel

Chloride channel

19

Stimulation of the GABA-A receptor increases chloride -----.
 

Influx

20

Stimulation of the GABA-A receptor increases chloride influx and ----- neurons

Hyperpolarizes

21

Stimulation of the GABA-A receptor increases chloride influx and hyperpolarizes neurons. This impairs the ability of these neurons to -----.

Fire

22

Volatile anesthetics most likely increase the ----- that the chloride channel remains open

Duration

23

In the spinal cord, volatile anesthetics produce immobility in the ----- horn

Ventral horn

24

Glycine receptor ----- is one of the most important action of volatile anesthetic in the spinal cord are

Stimulation

25

NMDA receptor ----- is one of the most important action of volatile anesthetic in the spinal cord are

 

Inhibition

26

Na+ channel ----- is one of the most important action of volatile anesthetic in the spinal cord are

 

 

Inhibition

27

Immobility is NOT due to GABA-A receptors in the spinal cord

True

28

Gaseous anesthetics (Nitrous oxide and Xenon) are NMDA receptor -----.

Antagonists

29

Gaseous anesthetics (Nitrous oxide and Xenon) are ----- the Potassium 2P-channel

"Stimulate"

30

Nitrous oxide and xenon "do not stimulate" the GABA-A receptor

True