Medications Flashcards

(51 cards)

1
Q

Psychodynamics

A

Where the drugs act in the body

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2
Q

Agonists

A

Medication that will elicit the same effect as a neurotransmitter

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3
Q

Antagonists

A

Medication that blocks the effect of a neurotransmitter

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4
Q

Partial agonists

A

Mimics the effect of a neurotransmitter but not to the full extent

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5
Q

Reuptake

A

Increases the availability of the neurotransmitter

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6
Q

Efficacy

A

Efficiency, the ability of the drug to produce a response

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7
Q

Toxicity

A

Once a medication gets to 100%, it can get toxic

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8
Q

Therapeutic index

A

Ratio of max nontoxic dose to min effective dose

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9
Q

Pharmacokinetics

A

How the body acts on the drug

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10
Q

Metabolism happens in

A

mostly the liver, sometimes in kidneys

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11
Q

Aging

A

-Slows everything down
-Gastric absorption, renal function, liver metabolism

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12
Q

AP Indications

A

Schizophrenia, Mania, Autism, Psychosis

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13
Q

AP Metabolism

A

Liver

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14
Q

AP Medications Types

A

-Typical
-Atypical

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15
Q

Typical AP Meds

A

-Antagonists
-Blocks dopamine
-Works for + symptoms

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16
Q

Chlorpromazine

A

-Thorazine
-Typical
-First AP med
-comes in IM form

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17
Q

Fluphenazine

A

-Prolixin
-Typical
-IM, PO, Liquid, LAI

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18
Q

Haloperidol

A

-Haldol
-Typical
-IM, PO, Liquid, LAI
-AE: Tardive

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19
Q

Atypical AP Meds

A

-Antagonists
-Blocks dopamine
-Weaker than typical
-Works for + and - symptoms

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20
Q

Aripiprazole

A

-Abilify
-Atypical
-PO, LAI

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21
Q

Clozapine

A

-Clozaril
-Atypical
-Last resort
-AE: Agranulocytosis

22
Q

Risperidone

A

-Risperdal
-Atypical
-PO, Liquid, SQ LAI
-AE: Metabolic Syndrome

23
Q

Ziprasidone

A

-Geodon
-Atypical
-AE: prolongs QT interval

24
Q

Paliperidone

A

-Invega
-Atypical
-PO, LAI
-AE: photosensitivity

25
Lurasidone
-Latuda -Atypical -Education: take with food
26
Cariprazine
-Vraylar -Atypical -High efficacy -Education: take w/ or w/o food: must choose one and stick with it
27
Asenapine
-Saphris -Atypical -SL
28
LAI Education
-Ask if they took any PO of the meds before -How did they tolerate it -LAIs last for weeks
29
AP Side effects
-Orthostatic hypotension -Lowered seizure threshold -Neuroleptic Malignant Syndrome (NMS) -Photosensitivity -Anticholinergic (DRY) -DM -Prolonged QT interval -Movement disorders** -Weight gain -Sex stuff
30
Acute Extrapyramidal Syndrome
-Movement disorder -Usually in atypical AP -Symptoms include... -Dystonia (involuntary muscle spasm) -Oculogyric crisis (eyes roll back and gets stuck) -Pseudoparkinsonism -Akathisia (restlessness) -Akinesia (slow movements) -Treatment include... -Benztropine -Propranolol
31
Tardive Dyskinesia
-Movement disorder -Usually in typical AP -Causes: long-term AP use -Irreversible if not treated -Symptoms include... -Constant involuntary rhythmic movements -Treatments include: -Decrease dose -Change medications -Try d/c meds but it can make it worse -Valbenazine -Austedo
32
Metabolic Syndrome
-Usually in atypical AP -Symptoms include... -Obesity -DM -Hyperlipidemia
33
Neuroendocrine
-Symptoms include... -Hyperprolactinemia -Gynecomastia -Galactorrhea -Menstrual irregularities
34
Neuroleptic Malignant Syndrome
-Usually with typical -Symptoms include... -Confusion -LOC changes -High fever -Agitation -Muscular rigidity -BP irregularities -Treatment include... -Dantrolene -Bromocritine
35
Agranulocytosis
-Symptoms include... -Low WBC levels -Infection -Death
36
Lithium
-Mood stabilizer -For mania, depressive episodes of BPD -Gold standard -Only med that is efficacious against suicidal ideation -Kidney metabolism -Therapeutic level: 0.6-1.2 -Side effects include... -Fine head tremors -Drowsiness -Metallic taste -Thirst -Increased urinary frequency -Mild diarrhea -Adverse toxic effects include... -Drowsiness -Vomiting -Muscular weakness -Lack of coordination -Severe diarrhea
37
Anticonvulsants
-Valproic Acid: liver metabolism -Carbamazepine: agranulocytosis -Lamotrigine: Stevens Johnsons Syndrome (rash) happens if titrated too quickly, never restart if missed >3 days
38
Antidepressants
-Takes up to 2-6 weeks -D/C should be tapered off -Increases risk of SI in children -AE: Serotonin Syndrome (w/ >2 SSRI)
39
SSRI
-antidepressant -serotonin -depression, anxiety
40
SNRIS
-antidepressant -serotonin, norepinephrine -venlafaxine/desvenlafaxine CI in close angled glaucoma
41
NDRI
-antidepressant -serotonin, norepinephrine, dopamine -CI in eating disorders -can end smoking
42
NASSA
-antidepressant -serotonin, norepinephrine, noradrenalin -packs on weight (15lbs), sedating
43
SARI
-antidepressant -serotonin -Ex: trazodone (priapism)
44
TCAs
-antidepressant -serotonin, norepinephrine -fatal in overdose
45
MAOIs
-antidepressant -HTN if tyramine (aged cheese, meat, wine, chocolate) -Isocarboxazid, Phenelzine, Tranylcypromine, Selegiline
46
Serotonin Syndrome Sx
-mental status changes (hallucinations, agitation) -neuromuscular problems (hyperreflexia, incoordination) -instability (tachycardia, hyperthermia, BP) -GI (N/V, diarrhea)
47
Benzodiazepines
-Antianxiety -very addicting -short-term use
48
Nonbenzodiazepines
-Antianxiety -Not addicting -Long-term use
49
Sedative-Hypnotics
-Antihistamines: hydroxyzine (PRN, not addictive)
50
Stimulants
-weight loss -children must have EKG -monitor BP, can stunt growth in children
51
Herbal supplements
-ask if pt is taking supplements or OTC meds -St John's Worts: works on serotonin so risk for SS