Melanocytes and Disorders of Pigmentation Flashcards Preview

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Flashcards in Melanocytes and Disorders of Pigmentation Deck (17):
1

normal skin color results from a what?

MELANIN, hemoglobin and carotenoid

2

What is ceruloderm?

a gray, slate or blue discoloration that arises from an increase in the # of melanocytes

3

Where can melonoma be present?

skin, ear, brain or eye

4

What does the C-KIT gene encode?

a receptor for steel factor

5

What is the binding of C-KIT to steel factor important?

It is critical for melanocyte migration and proliferation

6

Where do melanocytes reside?

basal layer

7

What is the key enzyme in melanin biosynthesis?

tyrosinase

8

What are the two major forms of melanin?

Eumelanin--> brown-black
pheomelanin--> yellow-red

9

What is the major factor in pheomelanogenesis?

mutation of MC1-R

10

Describe common features of vitiligo

autoimmune inflammatory disease--> destruction of melanocytes
keobnerization

11

What is the treatment for vililigo?

photoprotection, topical steroids and phototherapy (and grafting)

12

Describe common features of piebaldism

autosomal dominant
white forelock of hair
depigmentation involving the midline

13

What disease results from mutation of the c-KIT gene?

Piebaldism

14

Describe common features of Pityriasis Alba

ill-defined round patches, sometimes with overlying scale
common among children and those with atopic dermatitis

15

What defect commonly causes albinism?

tyrosinase

16

What ocular signs can you see in someone with albinism?

nystagmus, photophobia and diminished visual acuity

17

A wood's lamp will accentuated hypopigmented skin T/F

False