Flashcards in Melanocytes and Disorders of Pigmentation Deck (17):
normal skin color results from a what?
MELANIN, hemoglobin and carotenoid
What is ceruloderm?
a gray, slate or blue discoloration that arises from an increase in the # of melanocytes
Where can melonoma be present?
skin, ear, brain or eye
What does the C-KIT gene encode?
a receptor for steel factor
What is the binding of C-KIT to steel factor important?
It is critical for melanocyte migration and proliferation
Where do melanocytes reside?
What is the key enzyme in melanin biosynthesis?
What are the two major forms of melanin?
What is the major factor in pheomelanogenesis?
mutation of MC1-R
Describe common features of vitiligo
autoimmune inflammatory disease--> destruction of melanocytes
What is the treatment for vililigo?
photoprotection, topical steroids and phototherapy (and grafting)
Describe common features of piebaldism
white forelock of hair
depigmentation involving the midline
What disease results from mutation of the c-KIT gene?
Describe common features of Pityriasis Alba
ill-defined round patches, sometimes with overlying scale
common among children and those with atopic dermatitis
What defect commonly causes albinism?
What ocular signs can you see in someone with albinism?
nystagmus, photophobia and diminished visual acuity