Melatonin, Coenzyme Q-10, Ephedra, Echinacea Flashcards Preview

Adv Pharm > Melatonin, Coenzyme Q-10, Ephedra, Echinacea > Flashcards

Flashcards in Melatonin, Coenzyme Q-10, Ephedra, Echinacea Deck (14):
1

Melatonin use

treats insomnia

2

melatonin anest concern

hepatotoxicity
rapidly crosses BBB
increased sedative effects (hypnotics, benzos)
may interact with anticoagulants, immunosuppresants, diabetic meds, BCP

3

melatonin other info

hormone that controls sleep wake cycle
studies as preop anxiolysis drug

4

Coenzyme Q-10 use

increased insulin sensitivity in diabetics
antioxidant/anticancer med

5

coenzyme q-10 anest concern

increased clotting risk
decreased response to Coumadin/other anticoags

6

coenzyme q-10 other info

natural anti-inflammatory
used for HF, migraines
increases athletic performance

7

Ephedra use

weight loss
increased energy
asthma treatment

8

ephedra anest concern

direct/indirect sympathomimetic effects
CNS stimulant

9

ephedra side effects

HTN
tachycardia
arrhythmias
vasoconstriction
vasospasm
life-threatening interaction with MAOIs
tachyphylaxis: from depleted endogenous catecholamine stores (hemodynamic instability)

10

ephedra dangers include:

CVA
seizures
agitation, shaking
anxiety, nervousness, panic attack
insomnia
psychosis

MI
myocarditis

11

ephedra other info

must use direct acting sympathomimetics (phenylephrine)
short term ban after baseball player died

12

Echinacea use

immune system support
common as prophylaxis/treatment of infections, URIs

13

echinacea anest concern

allergic reactions (asthmatics)
decreased effectiveness of immunosuppressive meds (corticosteroids)
prolonged use - increased stimulation of immune system and immunosuppression
worsen metabolic control in diabetic pts - hypoglycemia
hepatotoxic

14

echinacea other info

contraindicated in pts with systemic disorders
(TB, leukosis, MS, HIV, autoimmune diseases)