Lecture Overview
Ions In Plasma
Patient with Hypoatremia
Patient with Hypoatremia — low sodium
IV correction leads to Central pontine Mylenosis*sp
Effects of Isotonic, Hypertonic, and Hypotonic Solutions on Cell Volume
Osmotic Pressure
Phospholipid Bilayer
Components of the Phospholipid bilayer
Trends in intracellular vs. Extracellular Ion Concentration
Relative Permeability to various Ions and Molecules of Phospholipid Bilayer
Overview of Membrane Transport Proteins
Simple Diffusion
Facilitated Transport
Active Transport
Co-Transport
Simple Diffusion through Membrane Bilayer
Key Points of Simple Diffusion
Facilitated Transport
Frog Oocytes and Aquaporins
Structure of Aquaporin
Key Points of Facilitated Diffusion
P-Class Pumps
V-Class Proton Pumps
F-Class Pumps
ABC Superfamily Pumps
4 Types of ATP Pumps
P-Class
V-Class
F-Class
ABC Superfamily
Transcellular Transport of Glucose from the Intestinal Lumen
Key Points of Active Transport
Co-Transport
Secondary Active Transport
Key Points of Cotransport
Multidrug Transporter ABCB1
Selected Human ABC Proteins
ATPase and pH
Non-Gated Channels and Resting Membrane Potential
If we introduce large pores what will happen?
What will introducing this pump ultimately do?
What will happen once we produce a Potassium Channel?
ABC Proteins and Multi-Drug Resistence