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MCM Exam 1-RH > Membranes & Transport > Flashcards

Flashcards in Membranes & Transport Deck (12):
1

Which membrane lipid is always present in the inner sheet?

Phosphatidylserine

**marker for apoptosis when found in outer leaflet

2

Functions of Glycocalyx

Protection
Cell Adhesion
Cell Identification

3

Erythroblastosis fetalis

Mother has - Rh factor, fetus has + Rh factor, mother starts making antibodies against fetus, really affects subsequent pregnancies bc more antibodies are made

4

Effect of saturated fatty acids on membrane

decreased fluidity (linear molecules that dont allow for flexibility)

5

effect of unsaturated fatty acids on membrane

increased fluidity due to branches and kinks that allow for rotating

6

spur cell anemia

type of hemolytic anemia where there is extra cholesterol in RBCs that decreases fluidity and cause the RBS to break

7

Mimantine/Namenda

antagonist of glutamate receptor (helps treat alzheimer's as a ligand gated channel)

8

primary active transport

use ATP directly
ex: P type ATPAses (does phosphorylate transporter on aspartate residue) , ABC transporters (doesn't phosphorylate transporter but ATP is used)

9

secondary active transport

uses energy stored in a concentration gradient

10

sodium glucose transporter (SGLT 1)

unidirectional movment of Na+ and glucose across small intestine and renal tubes
Na+: down concentration --> energy --> glucose: up gradient

**reset by Na+/K+/ATPases

11

Na+/Ca2+ Exchanger (NCX)

antiporter that imports 3Na+ down gradient and 1Ca2+ against

12

Cardiotonic Drugs

cardiac glycosides used --> inhibit the Na+/K+/ATPase--> sodium/potassium gradient collapses--> Na+/Ca2+ gradient is inhibited--> more calcium in heart cells --> trigger muscle contraction--> heart is jumpstarted