METABOLIC PROFILE DRUGS - Hypothalamic & Pituitary Hormones, Thyroid & Antithyroid Drugs Flashcards Preview

Pharmacology > METABOLIC PROFILE DRUGS - Hypothalamic & Pituitary Hormones, Thyroid & Antithyroid Drugs > Flashcards

Flashcards in METABOLIC PROFILE DRUGS - Hypothalamic & Pituitary Hormones, Thyroid & Antithyroid Drugs Deck (52):
1

Hormones are

Products of endocrine gland secretion

2

An endocrine drug which is an amino acid derivative

Thyroxine

3

An endocrine drug which is a peptide derivative

Oxitocin

4

An endocrine drug which is a steroidal derivative

Hydrocortisone

5

Hormone analogues are

Synthetic compounds, which resemble the naturally occurring hormones

6

True or False about mechanism of action of hormones. Hormones interact with the specific receptors in the wall of the cells

FALSE

7

True or False about mechanism of action of hormones. Cyclic AMP acts as a second messenger system

TRUE

8

True or False about mechanism of action of hormones. They stimulate adenylcyclase enzyme

TRUE

9

True or False about mechanism of action of hormones. Many hormones owe their effect to primary actions on subcellular membrane.

TRUE

10

Hypothalamic and pituitary hormones (and their synthetic analogs) have pharmacologic applications in three areas

- As replacement therapy for hormone deficiency states
- As drug therapy for a variety of disorders using pharmacologic doses to elicit a hormonal effect that is not present at physiologic a blood levels
- As a diagnostic tool for performing stimulation tests to diagnose hypo- or hyperfunctional endocrine states

11

Hypothalamic and pituitary hormones (and their synthetic analogs) have pharmacologic applications in three areas, excet

As food supplements

12

Which hormones is produced by the hypothalamic gland?

Growth hormone-releasing hormone (GHRH)

13

Which hormones is produced by the anterior lobe of the pituitary?

Growth hormone (somatotropin, GH)

14

The posterior pitutary does NOT secret

Growth hormone

15

The posterior pitutary secret

- Vasopressin
- Oxytocin

16

Which organs is a target for prolactin?

Mammary gland

17

Which organ hormones is a target for growth hormone (somatotropine, GH)?

Insulin-like growth factors (IGF, somatomedins)

18

True or False about growth hormone. It may stimulate the synthesis or release of somatomedins

TRUE

19

True or False about growth hormone.Low levels of insulin-like growth factor (IGF)-1 are associated with dwarfism

TRUE

20

True or False about growth hormone. Hypersecretion can result in acromegaly

FALSE

21

True or False about growth hormone. It is contraindicated in subjects with closed epiphyses

TRUE

22

adrenocorticotropic hormone (ACTH) include

- Endogenous ACTH is also called corticotropin
- ACTH stimulates the synthesis of corticosteroids
- ACTH is most useful clinically as a diagnostic tool in adrenal insufficiency

23

adrenocorticotropic hormone (ACTH) do not include

The oral route is the preferred rout of administration

24

True or False. The hypothalamic control exists for the thyroid gland.

TRUE

25

Indications of bromocriptine are

- Prolactin-secreting adenomas
- Amenorrhea-Galactorrhea
- Acromegaly

26

Indications of bromocriptine are not

Prolactin deficiency

27

Currently used dopamine agonists decreasing pituitary prolactin secretion are following

- Bromocriptine
- Cabergoline
- Pergolide

28

Indications of oxitocin are

- Labor and augment dysfunctional labor for conditions requiring early vaginal delivery
- Incompleted abortion
- For control of pospartum uterine hemorrhage

29

Indications of vasopressin are

Pituitary diabetes insipidus

30

Vasopressin possesses the following

Antidiuretic property

31

Oxytocin produces the following effects

- It causes contraction of the uterus
- It assists the progress of spermatozoa into the uterine cavity
- It brings about milk ejection from the lactating mammary gland

32

Vasopressin causes a pressor effect by

A direct action on smooth muscles of the blood vessels

33

True or False. Hypothyroidism is a syndrome resulting from deficiency of thyroid hormones and is manifested largely by a reversible slowing down of all body functions

True

34

Which hormones is produced by the thyroid gland?

Thyroxine

35

Which hormones is produced by the thyroid gland?

Triiodothyronine

36

Thyroid stimulating hormone regulates the following

- Iodine uptake
- Biosynthesis of iodothyroglobulin
- Release of thyroid hormone into the plasma

37

True or False about Thyroid hormones. Decline of the basal metabolic rate in the body

FALSE

38

True or False about Thyroid hormones. Increase in the rate and force of contraction of the heart

TRUE

39

True or False about Thyroid hormones. Increase in the blood cholestrol level

TRUE

40

True or False about Thyroid hormones. Increase in the heat production

TRUE

41

Synthesis and release of thyroid hormones are controlled by

- Anterior pituitary alone
- Hypothalamus alone
- Blood levels of thyroid hormones alone

42

Thyrotrophin stimulates

Release of thyroxine and triidothyronine

43

The rate of secretion of thyrotropin is controlled by

The concentration of thyroid hormones in blood

44

Indications of thyroid hormones are

- Cretinism
- Myxoedema
- Hashimoto's disease

45

The common side effect of thyroid hormones is

Exopthalmos

46

Currently used antithyroid drugs include the following

- Propylthiouracil (PTU)
- Diatrizoate sodium (Hypaque)
- Methimazole (Tapazole)

47

In an area where goitre is endemic, which of the following drugs is used?

Iodide 1 part in 100000

48

Iodide preparations can be used in following situations

- In thyroid disorders
- In granulomatous lesions e.g. Syphilis
- As an antiseptic

49

Iodide preparations can not be used in following situations

In iodism

50

Daily administration of large doses (several milligrammes) of iodides to a thyrotoxic patient causes

Thyroid gland growing firm and less vascular

51

Radioiodines (I131 and I132) is suitable for

Elderly patients (over 45 years)

52

Radioiodines in the body emit

Mainly β radiations

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