METABOLIC PROFILE DRUGS - Mineralocorticoid, Mineralocorticoid Antagonists, Diuretics, Plasma Expanders Flashcards Preview

Pharmacology > METABOLIC PROFILE DRUGS - Mineralocorticoid, Mineralocorticoid Antagonists, Diuretics, Plasma Expanders > Flashcards

Flashcards in METABOLIC PROFILE DRUGS - Mineralocorticoid, Mineralocorticoid Antagonists, Diuretics, Plasma Expanders Deck (54):
1

Mineralocorticoid effects cause

Increased Na retension and К excretion

2

Which synthetic steroids shows predominantly mineralocorticoid action?

Fludrocortisone

3

The major mineralocorticoids are

Hydrocortisone

4

True or False about spironolactone. Spironolactone reverses many of the manifestations of aldosteronism

TRUE

5

True or False about spironolactone. Spironilactone is also an androgen antagonist and as such is used in the treatment of hirsutism in wormen

TRUE

6

True or False about spironolactone. Spironolactone is useful as a diuretic

TRUE

7

True or False about diuretics. Carbonic anhydrase inhibition leads to increased reabsorption of NaHCO3

FALSE

8

True or False about diuretics. Loop diuretics decrease Na+ reabsorption at the loop of Henle by competing for the Cl- site on the Na+/K+/2Clcotransporter

TRUE

9

True or False about diuretics. In general, the potency of a diuretic is determined by where it acts in the renal tubule

TRUE

10

True or False about diuretics. Hydrochlorothiazide decreases urinary calcium excretion

TRUE

11

The drug inhibits the ubiquitous enzyme carbonic anhydrase

Acetazolamide (Diamox)

12

The drug acts by competitively blocking NaCl cotransporters in the distal tubule

Hydrochlorothiazide (HydroDiuril)

13

The drug acts at the proximal tubule

Acetazolamide (Diamox)

14

The drug acts by competing with aldosterone for its cytosolic receptors

Spironolactone (Aldactone)

15

The drug is a potassium-sparing diuretic that blocks Na+ channels in the collecting tubules

Amiloride (Midamor)

16

Chronic use of this drug can lead to distal tubular hypertrophy, which may reduce its diuretic effect

Furosemide (Lasix)

17

The drug has a steroid-like structure which is responsible for its anti-androgenic effect

Spironolactone (Aldactone)

18

Sustained use of this drug results in increased plasma urate concentrations

Furosemide (Lasix)

19

The drug can be used to treat glaucoma

Acetazolamide (Diamox)

20

The drug can cause ototoxicity

Furosemide (Lasix)

21

The drug acts only on the lumenal side of renal tubules

Furosemide (Lasix)

22

The drug can promote sodium loss in patients with low (e.g., 40 ml/min) glomerular filtration rates

Furosemide (Lasix)

23

The drug can be used to treat nephrogenic diabetes insipidus

Hydrochlorothiazide (HydroDiuril)

24

The drug is sometimes part of fixed-dose combinations used to treat essential hypertension

- Hydrochlorothiazide (HydroDiuril)
- Amiloride (Midamor)

25

The drug should never be administered to patients taking potassium supplements

Amiloride (Midamor)

26

The drug decreases calcium excretion in urine

Hydrochlorothiazide (HydroDiuril)

27

The drug acts by competitively blocking the Na+/K+/2Cl- cotransporter

Loop diuretics

28

The drug acts at the proximal tubule

Carbonic anhydrase inhibitors

29

The drug acts in the distal convoluted tubule

Thiazide diuretics

30

The drug acts in the collecting tubules

Potassium-sparing diuretics

31

The drug is the most potent diuretic

Loop diuretics

32

The drug acts by competitively blocking the NaCl cotransporter

Thiazide diuretics

33

The drug inhibits sodium and chloride transport in the cortical thick ascending limb and the early distal tubule

Hydrochlorothiazide (Hydrodiuril)

34

The drug can cause ototoxicity

Furosemide (Lasix)

35

The drug blocks the sodium/potassium/chloride cotransporter in the thick ascending loop of Henle

Furosemide (Lasix)

36

The drug is one of the most potent diuretics

Furosemide (Lasix)

37

The drug is usually given in combination with a thiazide diuretic

Amiloride (Midamor)

38

True or False about diuretics. Furosemide (Lasix) can increase the likelihood of digitalis toxicity

TRUE

39

True or False about diuretics. Chlorthalidone (Hygroton) can decrease the excretion of lithium

TRUE

40

True or False about diuretics. Ibuprofen can increase the antihypertensive effect of chlorthalidone

FALSE

41

True or False about diuretics. Chlorthalidone has a longer duration of action than furosemide

TRUE

42

The drug is the least potent diuretic

Potassium-sparing diuretics

43

These agents must be given parenterally because they are not absorbed when given orally

Osmotic diuretics

44

These drugs may be used in the treatment of recurrent calcium nephrolithiasis

Loop diuretics

45

Furosemide (Lasix) acts at this nephron site

Ascending thick limb of the loop of Henle

46

Metolazone (Mykrox) acts at this nephron site

Distal convoluted tubule

47

Acetazolamide (Diamox) acts at this nephron site

Proximal convoluted tubule

48

Spironolactone (Aldactone) acts at this nephron site

Collecting duct

49

Amiloride (Midamone) acts at this nephron site

Collecting duct

50

The drug competitively blocks chloride channels and prevents movement of sodium, potassium, and chloride into the renal tubular cells

Furosemide (Lasix)

51

The drug acts by affecting the tubular fluid composition in a non-receptor mediated fashion

Mannitol (Osmitrol)

52

The drug is a blood substitute having haemodynamical activity

Polyglucinum

53

This drug is a desintoxicative plasma substitute

Haemodesum

54

This drug is a controller of water-salt and acid-basic state

"Disolum", "Trisolum"

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