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Flashcards in Metabolism Deck (23)
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1

Alpha-ketoacid dehydrogenase requires ______ as a coenzyme

thiamine pyrophosphate (vit B1)

2

the branch-chain alpha-keto acid dehydrogenase complex is responsible for the catabolism of the branched chain amino acids _______, _______, and _______

leucine, valine, and isoleucine

3

Epi and NorEpi are metabolized to ________ and ________ by _______...THEN it is FURTHER broken down into ________ by _______.BOOM

METAnephrine and normetanephrine...catechol-O-methyltransferase (COMT)...Vanilla (Vanillylmandelic Acid) by MAO (MonoAmineOxidase)

4

What metabolic byproduct might you see in the urine of a pheochromocytoma pt?

Vanillylmandeic Acid

5

What breaks down a fatty acid to ACYL CoA?

ACYL CoA SYNTHASE

6

Remember the Carnitine Shuttle?? Which enzyme does work in the cytoplasm? Which enzyme does work in the mitochondrial matrix? ***WHAT ARE THESE ENZYMES CONVERTING?!?!*** (hint: its the SAME inside the mitochondria AND outside the mitochondira)

CAT I in cytoplasm...CAT II in Mitochondrial Matrix...Carnitine----->ACYL-Carnitine

7

What is the precursor for Ketone Bodies?

Acetyl CoA

8

FAO: Acyl-CoA----> (ENZYME?)---->Trans-enoyl CoA.. What is the byproduct released?

Acyl-CoA Dehydrogenase..FADH2

9

FAO: Tans-enoyl CoA ----->? (no enzyme given)

3-HydroxyAcyl CoA

10

FAO: 3-HydroxyAcyl CoA---->? (no enzyme given)...What is the BYPRODUCT?

3-Ketoacyl CoA...NADH

11

FAO: 3-KetoAcyl CoA---->? (no enzyme given)

Acetyl CoA (then to KBs!!!)

12

What are the two purely KETOGENIC amino acids? What are the 4 Glucogenic AND Ketogenic AAs?

Pure: 1.Leucine 2.Lysine........Both:1.ISOleucine 2.Phenylalanine 3. 3-O-9 4.TryptoPhan

13

Which ION sees an increased extracellular concentration during TISSUE injury??

K+

14

______ ____-______ is responsible for the synthesis of Nor-epi from dopamine.

Dopamine beta-hyroxylase

15

the balance between glycolysis and gluconeogenesis is primarily regulated at the conversion between _________ and ____________

fructose-6-phosphate (fructose-6P) and fructose-1,6-bisphosphonate (fructose-1,6BP)

16

________ converts fructose-6P to fructose-1,6BP during GLYCOLYSIS

PFK-1 (phosphofructokinase-1)

17

_________ catalyzes fructose-1,6BP to fructose-6P during GLUCONEOGENESIS

F-1,6-BPase (fructose-1,6-bisphosphonase)

18

________ increases intracellular concentrations of fructose-2,6,bisphosphate, which promotes PFK-1 and fthe formation of fructose-1,6-bisphosphate...WHICH metabolic process is this?

INSULIN...glycolysis

19

BUST OUT THE PENCIL AND PAPER: what are the 9 hydrophobic AA's?

VAL-PIT-MPG: Valine, Alanine, Leucine, Phenylalanine, Isoleucine, Tryptophan, Methionine, Proline, and Glycine

20

Carbamoyl phosphate synthase II is an enzyme that catalyzes the initial step in DE NOVO ______ synthesis and is located in the CYTOSOL

pyrimidine

21

Carbamoyl phosphate synthase I of the UREA cycle is located in the ________

mitochondria

22

Impaired ________ enzyme production RAISES the body's glucose threshold for insulin release thus leading to diabetes

GLUCOKINASE

23

Von-Gierke disease is a ______-__-_____ deficiency and impairs the release of free glucose generated thru glycogenolysis and gluconeogenesis

Glucose-6-Phosphatase