Flashcards in Metabolism Deck (23)
Alpha-ketoacid dehydrogenase requires ______ as a coenzyme
thiamine pyrophosphate (vit B1)
the branch-chain alpha-keto acid dehydrogenase complex is responsible for the catabolism of the branched chain amino acids _______, _______, and _______
leucine, valine, and isoleucine
Epi and NorEpi are metabolized to ________ and ________ by _______...THEN it is FURTHER broken down into ________ by _______.BOOM
METAnephrine and normetanephrine...catechol-O-methyltransferase (COMT)...Vanilla (Vanillylmandelic Acid) by MAO (MonoAmineOxidase)
What metabolic byproduct might you see in the urine of a pheochromocytoma pt?
What breaks down a fatty acid to ACYL CoA?
ACYL CoA SYNTHASE
Remember the Carnitine Shuttle?? Which enzyme does work in the cytoplasm? Which enzyme does work in the mitochondrial matrix? ***WHAT ARE THESE ENZYMES CONVERTING?!?!*** (hint: its the SAME inside the mitochondria AND outside the mitochondira)
CAT I in cytoplasm...CAT II in Mitochondrial Matrix...Carnitine----->ACYL-Carnitine
What is the precursor for Ketone Bodies?
FAO: Acyl-CoA----> (ENZYME?)---->Trans-enoyl CoA.. What is the byproduct released?
FAO: Tans-enoyl CoA ----->? (no enzyme given)
FAO: 3-HydroxyAcyl CoA---->? (no enzyme given)...What is the BYPRODUCT?
FAO: 3-KetoAcyl CoA---->? (no enzyme given)
Acetyl CoA (then to KBs!!!)
What are the two purely KETOGENIC amino acids? What are the 4 Glucogenic AND Ketogenic AAs?
Pure: 1.Leucine 2.Lysine........Both:1.ISOleucine 2.Phenylalanine 3. 3-O-9 4.TryptoPhan
Which ION sees an increased extracellular concentration during TISSUE injury??
______ ____-______ is responsible for the synthesis of Nor-epi from dopamine.
the balance between glycolysis and gluconeogenesis is primarily regulated at the conversion between _________ and ____________
fructose-6-phosphate (fructose-6P) and fructose-1,6-bisphosphonate (fructose-1,6BP)
________ converts fructose-6P to fructose-1,6BP during GLYCOLYSIS
_________ catalyzes fructose-1,6BP to fructose-6P during GLUCONEOGENESIS
________ increases intracellular concentrations of fructose-2,6,bisphosphate, which promotes PFK-1 and fthe formation of fructose-1,6-bisphosphate...WHICH metabolic process is this?
BUST OUT THE PENCIL AND PAPER: what are the 9 hydrophobic AA's?
VAL-PIT-MPG: Valine, Alanine, Leucine, Phenylalanine, Isoleucine, Tryptophan, Methionine, Proline, and Glycine
Carbamoyl phosphate synthase II is an enzyme that catalyzes the initial step in DE NOVO ______ synthesis and is located in the CYTOSOL
Carbamoyl phosphate synthase I of the UREA cycle is located in the ________
Impaired ________ enzyme production RAISES the body's glucose threshold for insulin release thus leading to diabetes