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Flashcards in metabolism/anaesthetics/etc Deck (13):
1

Phase 1 metabolism

By CYP enzymes; contains haem ion. Located in smooth ER of hepatocytes and other cells. Mediates oxidation, hydrolysis or hydroxylation.

2

Phase 2 reactions

Add many chemical groups to increase polarity. Catalysed by transferases.

3

0 order elimination

Elimination is constant and indep of plasma conc. Shown by ethanol, phenytoin and aspirin

4

1st order elimination

rate of elimination increases linearly with Cp. Clearance is constant.

5

Clearance = rate of elimination divided by...?

Plasma conc.

6

Clearance = dose rate/?

? = Css

7

Vd(ss) = clearance/?

?=Ke

8

AUC = Cp/?

? = Ke

9

Approach to Css

Made faster by faster elimination.

10

Cmin = Cmax?

Cmax x e(to the -kT)

11

C(avss) = dose rate x F/ ?

? = clearance

12

Rate of induction of anaesthesia

Dependent on blood:gas partition coefficient. If low, rapid induction and recovery.

13

High fat:blood partition coefficient

Anaesthetic hangover