Flashcards in metabolism/anaesthetics/etc Deck (13):
Phase 1 metabolism
By CYP enzymes; contains haem ion. Located in smooth ER of hepatocytes and other cells. Mediates oxidation, hydrolysis or hydroxylation.
Phase 2 reactions
Add many chemical groups to increase polarity. Catalysed by transferases.
0 order elimination
Elimination is constant and indep of plasma conc. Shown by ethanol, phenytoin and aspirin
1st order elimination
rate of elimination increases linearly with Cp. Clearance is constant.
Clearance = rate of elimination divided by...?
Clearance = dose rate/?
? = Css
Vd(ss) = clearance/?
AUC = Cp/?
? = Ke
Approach to Css
Made faster by faster elimination.
Cmin = Cmax?
Cmax x e(to the -kT)
C(avss) = dose rate x F/ ?
? = clearance
Rate of induction of anaesthesia
Dependent on blood:gas partition coefficient. If low, rapid induction and recovery.