Metabolism And Cancer Flashcards
Major drivers for metabolic reprogramming i tumour cells
Tolerate hypoxia and oxidative stress
Export excess acid
Glycolic intermediates used for anabolism
Tumour suppressor regulation of metabolism
TIGAR rapidly activated by p53 in response to stress
Reduces rate of glycolysis
In cancer p53 ⬇️ so glycolysis ⬆️
Oncogene regulation of metabolism
Myc and AKT promote glycolysis. Amplification in many cancers
Lipid synthesis in hypoxia
Glutamine replenishes TCA cycle intermediates
Regulated by cMyc
In hypoxia = glutamine can replenish and maintain lipid synthesis by reversing TCA cycle
Hypoxia inducible factor
Key in tumour growth and survival under hypoxia
How to deal with accumulation of acid
Local acidification of environment promotes tumour invasion due to disruption of ECM
Up regulation of transporters involved in pH balance
2 screening tools for aid of cancer detection
Nmr
Mass spec
How are nmr, mass spec and mri used
Detect increase in choline metabolism = malignant transformation
3 ways metabolism is exploited in diagnosis and therapy
Hormone therapies - anti hormone drugs
Image tumours using labelled glucose
Anti metabolite drugs