Metabolism And Cancer Flashcards

1
Q

Major drivers for metabolic reprogramming i tumour cells

A

Tolerate hypoxia and oxidative stress
Export excess acid
Glycolic intermediates used for anabolism

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2
Q

Tumour suppressor regulation of metabolism

A

TIGAR rapidly activated by p53 in response to stress
Reduces rate of glycolysis
In cancer p53 ⬇️ so glycolysis ⬆️

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3
Q

Oncogene regulation of metabolism

A

Myc and AKT promote glycolysis. Amplification in many cancers

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4
Q

Lipid synthesis in hypoxia

A

Glutamine replenishes TCA cycle intermediates
Regulated by cMyc
In hypoxia = glutamine can replenish and maintain lipid synthesis by reversing TCA cycle

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5
Q

Hypoxia inducible factor

A

Key in tumour growth and survival under hypoxia

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6
Q

How to deal with accumulation of acid

A

Local acidification of environment promotes tumour invasion due to disruption of ECM
Up regulation of transporters involved in pH balance

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7
Q

2 screening tools for aid of cancer detection

A

Nmr

Mass spec

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8
Q

How are nmr, mass spec and mri used

A

Detect increase in choline metabolism = malignant transformation

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9
Q

3 ways metabolism is exploited in diagnosis and therapy

A

Hormone therapies - anti hormone drugs
Image tumours using labelled glucose
Anti metabolite drugs

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