Metabolism: Exercise and Starvation Flashcards Preview

Fundamentals of Molecular Medicine > Metabolism: Exercise and Starvation > Flashcards

Flashcards in Metabolism: Exercise and Starvation Deck (39):
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Starvation Big Picture

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Case Study

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Overall Pathways to be Integrated

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Regulated Enzymes in Glycolysis 

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5

What is the key hormonally regulated enzyme related to liver glycolysis:

PFK1

PFK2

Hexokinase

Cluockinase

G3PDH

 

 

 

PFK2

6

Acetyl CoA activates which one of the following pathways?

Glycolysis

Gluconeogenesis 

Fatty Acid Synthesis 

Fatty Acid Degradation

Glycogen Synthesis  

 

 

Gluconeogenesis — acetyl coA activates pyruvate carboxylase which begins gluconeogenesis. 

Fatty Acid Synthesis — citrate

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Regulated Enzymes of Gluconeogenesis 

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Regulated Enzymes of TCA

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Regulated Enzymes of Glycogen Metabolism 

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Regulated Enzymes of Fatty Acid Metabolism 

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11

Insulin release will activate which pathway in the liver?

Glycolysis

Gluconeogenesis  

Glycogenolysis 

Fatty Acid Oxidation 

HMP Shunt 

 

 

 

Glycolysis— Insulin promotes energy storage to provide precursors for fatty acid biosynthesis. 

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What Happens to when insulin is released? 

Overview

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Insulin Release and PFK2, Citrate, Gluckokinase, and Glucose Transport

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Insulin Release and cAMP, Glycogen Synthase, Glycogen Phosphorylase

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Insulin Release and Acetyl CoA, Citrate, and Perilipin 

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Insulin Release and Gluconeogenesis, F1,6BP, and PEPCK Levels

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17

Glucagon release will activate which pathway in the liver?

Glycolysis

Fatty Acid Synthesis

Glycogenolysis

HMP Shunt

Glycogen Synthesis

 

 

 

Glycogenolysis

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What happens when Glucagon is released

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Glucagon Release and Muscle, cAMP, and F2,6BP

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Glucagon Release and Adenlyate Cyclase, Protein Phosphatase Inhibitor I, and Glycogen Synthase

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Glucagon and Epinephrine Release and FA, Protein Kinase A, Acetyl-CoA Carboxylase

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Glycolysis and Gluconeogenesis 

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Glycogen Degredation 

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Overview of Glycogen Degredation 

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Pathways of Fat Metabolism 

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First 12 hrs of Starvation in Liver and Muscle

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12-24 Hours of Stravation Muscle and Liver

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28

Ketone bodies spare muscle protein degradation due to which of the following?

The liver uses ketone bodies for energy

The muscle uses ketone bodies for energ

the nervous system uses ketone bodies for energy 

the intestine uses ketone bodies for energy — uses glutamine for energy

 

 

 

the nervous system uses ketone bodies for energy — KB have to be at a certain concentration in blood before brain can take it up (take a day)

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Metabolism in the Starved State

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Metabolism in the Starved State

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Substrate Levels over 8 Days of Fasting

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Fuel Sources During Starvation 

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Sources of Blood Glucose

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34

 

 

 

Starving Liver

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Starvation and PFK2, F26BP, Pyruvate Carboxylase, PDH, and CREB

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Starvation and KB Formation 

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Starved Adipocyte

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Starved Muscle 

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Starving Conditions Muscle, Liver, and Lactate

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