Metabolism: Exercise and Starvation Flashcards Preview

Fundamentals of Molecular Medicine > Metabolism: Exercise and Starvation > Flashcards

Flashcards in Metabolism: Exercise and Starvation Deck (39):
1

 

 

 

Starvation Big Picture

2

 

 

 

Case Study

3

 

 

 

Overall Pathways to be Integrated

4

 

 

 

Regulated Enzymes in Glycolysis 

5

What is the key hormonally regulated enzyme related to liver glycolysis:

PFK1

PFK2

Hexokinase

Cluockinase

G3PDH

 

 

 

PFK2

6

Acetyl CoA activates which one of the following pathways?

Glycolysis

Gluconeogenesis 

Fatty Acid Synthesis 

Fatty Acid Degradation

Glycogen Synthesis  

 

 

Gluconeogenesis — acetyl coA activates pyruvate carboxylase which begins gluconeogenesis. 

Fatty Acid Synthesis — citrate

7

 

 

 

Regulated Enzymes of Gluconeogenesis 

8

 

 

 

Regulated Enzymes of TCA

9

 

 

 

Regulated Enzymes of Glycogen Metabolism 

10

 

 

 

Regulated Enzymes of Fatty Acid Metabolism 

11

Insulin release will activate which pathway in the liver?

Glycolysis

Gluconeogenesis  

Glycogenolysis 

Fatty Acid Oxidation 

HMP Shunt 

 

 

 

Glycolysis— Insulin promotes energy storage to provide precursors for fatty acid biosynthesis. 

12

 

 

 

What Happens to when insulin is released? 

Overview

13

 

 

 

Insulin Release and PFK2, Citrate, Gluckokinase, and Glucose Transport

14

 

 

 

Insulin Release and cAMP, Glycogen Synthase, Glycogen Phosphorylase

15

 

 

 

Insulin Release and Acetyl CoA, Citrate, and Perilipin 

16

 

 

 

Insulin Release and Gluconeogenesis, F1,6BP, and PEPCK Levels

17

Glucagon release will activate which pathway in the liver?

Glycolysis

Fatty Acid Synthesis

Glycogenolysis

HMP Shunt

Glycogen Synthesis

 

 

 

Glycogenolysis

18

 

 

 

What happens when Glucagon is released

19

 

 

 

Glucagon Release and Muscle, cAMP, and F2,6BP

20

 

 

 

Glucagon Release and Adenlyate Cyclase, Protein Phosphatase Inhibitor I, and Glycogen Synthase

21

 

 

 

Glucagon and Epinephrine Release and FA, Protein Kinase A, Acetyl-CoA Carboxylase

22

 

 

 

Glycolysis and Gluconeogenesis 

23

 

 

 

Glycogen Degredation 

24

 

 

 

Overview of Glycogen Degredation 

25

 

 

 

Pathways of Fat Metabolism 

26

 

 

 

First 12 hrs of Starvation in Liver and Muscle

27

 

 

 

12-24 Hours of Stravation Muscle and Liver

28

Ketone bodies spare muscle protein degradation due to which of the following?

The liver uses ketone bodies for energy

The muscle uses ketone bodies for energ

the nervous system uses ketone bodies for energy 

the intestine uses ketone bodies for energy — uses glutamine for energy

 

 

 

the nervous system uses ketone bodies for energy — KB have to be at a certain concentration in blood before brain can take it up (take a day)

29

 

 

 

Metabolism in the Starved State

30

 

 

 

Metabolism in the Starved State

31

 

 

 

Substrate Levels over 8 Days of Fasting

32

 

 

 

Fuel Sources During Starvation 

33

 

 

 

Sources of Blood Glucose

34

 

 

 

Starving Liver

35

 

 

 

Starvation and PFK2, F26BP, Pyruvate Carboxylase, PDH, and CREB

36

 

 

 

Starvation and KB Formation 

37

 

 

 

Starved Adipocyte

38

 

 

 

Starved Muscle 

39

 

 

 

Starving Conditions Muscle, Liver, and Lactate

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