Metronidazole Flashcards
1
Q
drug classification
A
nitroimidazole class of antibiotics
2
Q
target
A
DNA
3
Q
mechanism of action
A
enters cells by diffusion
ferredoxin or flavodoxin reduces its nitro group to nitro radicals
nitro group reduction leads to production of toxic metabolites
leads to DNA breakage
4
Q
physiology
A
toxic metabolites (oxalic acid and acetamide)
damage DNA of replicating organisms
inhibit bacterial proliferation
5
Q
used to treat
A
inflammatory lesions of rosacea
bacterial infections
prevent post op infections
