MHD- Lec #7 - Valvular and Neoplastic Heart Disease Flashcards Preview

PHARM/MHD - Exam #4 > MHD- Lec #7 - Valvular and Neoplastic Heart Disease > Flashcards

Flashcards in MHD- Lec #7 - Valvular and Neoplastic Heart Disease Deck (21):
1

Aschoff bodies ( collecting of lymphocytes, plasma cells, and macrophages - similar to granuloma) are a key finding in ______

The macrophages in the Aschoff bodies are called what?

ACUTE RHEUMATIC FEVER CARDITIS

Anitschkow cells

2

Hw would one distinguish acute from chronic rheumatic fever carditis

presence of fibrosis on the valve structures = CHRONIC

- thickened & fused = fish mouth or buttonhole stenosis

- mostly mitral valve

3

What tumors secrete bioactive products like serotonin, chalkier, bradykinin, histamine, prostaglandins?

CARCINOID tumors

- endocrine tumors in the GI tract & lung

4

Carcinoid heart disease affects ____ side of the heart
and the valves develop what?

Pathogenesis?

RIGHT SIDE

- mucopolysaccharide matrix

- correlation between serotonin levels with the development of right sided heart disease

5

CHronic rheumatic heart disease most commonly manifests itself as ____ stenosis

Mitral

6

What is the physical exam finding of acute rheumatic fever carditis

pericardial friction rub

7

Describe the components of the cardiac valves
1. spongiosa
2. fibrosa
3. ventricularis

1. spongiosa - loose collagen
2. fibrosa - DENSE CORE of collagen
3. ventricularis - dense connective tissue made of ELASTIN & COLLAGEN

8

What are cardiac valves composed of on each side?

Composed of connective tissue layers covered by endothelium on each side;

3 layers

9

Describe the nuclei & presence/absenece of striations for
1. cardiac myocytes
2. smooth muscle
3. skeletal muscle

1. cardiac - central nuclei with cross striations
2. smooth - central nuclei with NO cross striations
3. skeletal - PERIPHERAL nuclei w/ cross striations

10

Which layer of the heart is thickest?

What component within this layer is responsible for ion transport/ communication?

Myocardium

Intercalated disks

Junctional complexes that contain fascia adherens, desmosomes, and gap junction to provide connection and communication.

Bind myocytes and allow ion exchange to facilitate electrical impulses to pass

11

Which layer of the heart are the parking fibers located in?

SUBENDOCARDIAL layer of endocardium

- impulse conducting fibers

12

What type of epithelium is the endocardium composed of?

What else makes up the endocardium

Simple squamous epithelium

- connective tissue
- subendocardium ( purkinje fibers, vessels, nerves)

13

Which layer of vessels contains the following:

1. smooth muscle
2. external elastic lamina in ARTERIES

Tunica MEDIA

14

Which layer of vessels contains the following:

1. endothelium
2. subendothelium
3. internal elastic lamina in ARTERIES

Tunica intima

15

Which layer of vessels contains the following:
1. connective tissue & fibroblasts
2. longitudinal smooth muscle in veins
3. vasovasorum in large vessels

Tunica ADVENTITIA

16

External & internal elastic lamina are absent from (veins/arteries)?

Veins!

17

The following describes which type of vessel:

Only two layers of smooth muscle cells. Internal elastic lamina, external elastic lamina, and subendothelial layers usually absent.

Arterioles

18

smaller diameter and no external elastic lamina.
The tunica media also has fewer layers of smooth muscle cells. (single internal elastic lamina in black)

What am i?

Small artery

19

Also called muscular artery because the wall is dominated by smooth muscle.

internal and external elastic lamina are well defined and lack prominent vasovasorum.

What am i??

Medium artery

20

Large arteries are also called the ___ arteries

ELASTIC

21

In regards to tunica media & tunica adventitia, how are the veins different from arteries?

Veins
- larger tunica ADVENTITIA