Micro - Antimicrobials (Interferons & Antibiotics to avoid in Pregnancy) Flashcards Preview

FA - Microbiology > Micro - Antimicrobials (Interferons & Antibiotics to avoid in Pregnancy) > Flashcards

Flashcards in Micro - Antimicrobials (Interferons & Antibiotics to avoid in Pregnancy) Deck (14):
1

What is the mechanism of Interferons?

Glycoproteins normally synthesized by virus-infected cells, exhibiting a wide range of antiviral and antitumoral properties

2

What are 6 clinical uses of IFN-alpha?

IFN-alpha: (1) Chronic hepatitis B and C, (2) Kaposi sarcoma, (3) Hairy cell leukemia, (4) Condyloma acuminatum, (5) Renal cell carcinoma, (6) Malignant melanoma

3

What is a clinical use of IFN-beta?

IFN-beta: Multiple sclerosis

4

What is a clinical use of IFN-gamma?

IFN-gamma: Chronic granulomatous disease

5

What are 2 toxicities associated with Interferons?

(1) Neutropenia (2) Myopathy

6

What are 8 antibiotics to avoid in pregnancy? Make a note of which of these treat anything other than bacteria (i.e., antiviral, antifungal, etc.).

(1) Sulfonamides (2) Aminoglycosides (3) Fluoroquinolones (4) Clarithromycin (5) Tetracyclines (6) Ribavirin (antiviral) (7) Griseofulvin (antifungal) (8) Chloramphenicol; Think: "SAFe Children Take Really Good Care."

7

What adverse effect do sulfonamides have?

Kernicterus

8

What adverse effect do aminoglycosides have?

Ototoxicity

9

What adverse effect do fluoroquinolones have?

Cartilage damage

10

What adverse effect do clarithromycin have?

Embryotoxic

11

What 2 adverse effects do tetracyclines have?

Discolored teeth, inhibition of bone growth

12

What adverse effect does ribavirin (antiviral) have?

Teratogenic

13

What adverse effect does griseofulvin (antifungal) have?

Teratogenic

14

What adverse effect does Chloramphenicol have?

"Gray baby"

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