Flashcards in Micro - Antimicrobials (Interferons & Antibiotics to avoid in Pregnancy) Deck (14):
What is the mechanism of Interferons?
Glycoproteins normally synthesized by virus-infected cells, exhibiting a wide range of antiviral and antitumoral properties
What are 6 clinical uses of IFN-alpha?
IFN-alpha: (1) Chronic hepatitis B and C, (2) Kaposi sarcoma, (3) Hairy cell leukemia, (4) Condyloma acuminatum, (5) Renal cell carcinoma, (6) Malignant melanoma
What is a clinical use of IFN-beta?
IFN-beta: Multiple sclerosis
What is a clinical use of IFN-gamma?
IFN-gamma: Chronic granulomatous disease
What are 2 toxicities associated with Interferons?
(1) Neutropenia (2) Myopathy
What are 8 antibiotics to avoid in pregnancy? Make a note of which of these treat anything other than bacteria (i.e., antiviral, antifungal, etc.).
(1) Sulfonamides (2) Aminoglycosides (3) Fluoroquinolones (4) Clarithromycin (5) Tetracyclines (6) Ribavirin (antiviral) (7) Griseofulvin (antifungal) (8) Chloramphenicol; Think: "SAFe Children Take Really Good Care."
What adverse effect do sulfonamides have?
What adverse effect do aminoglycosides have?
What adverse effect do fluoroquinolones have?
What adverse effect do clarithromycin have?
What 2 adverse effects do tetracyclines have?
Discolored teeth, inhibition of bone growth
What adverse effect does ribavirin (antiviral) have?
What adverse effect does griseofulvin (antifungal) have?