Micro - Antimicrobials (Mechanisms of Antibacterial Therapy) Flashcards Preview

FA - Microbiology > Micro - Antimicrobials (Mechanisms of Antibacterial Therapy) > Flashcards

Flashcards in Micro - Antimicrobials (Mechanisms of Antibacterial Therapy) Deck (27):
1

What is the mechanism of action of the following drugs: Penicillin, methicillin, ampicillin, piperacillin, cephalosporins, aztreonam, and imipenem?

Block cell wall synthesis by inhibition of PEPTIDOGLYCAN CROSS-LINKING

2

Name 6 classes of antimicrobials that block cell wall synthesis by inhibition of peptidoglycan cross-linking.

(1) Penicillinase-sensitive penicillins (2) Penicillinase-resistant penicillins (3) Antipseudomonals (4) Cephalosporins (I-V) (5) Carbapenems (6) Monobactams

3

What is the mechanism of action of Bacitracin and Vancomycin?

Block PEPTIDOGLYCAN SYNTHESIS

4

What is the class of antimicrobials that block peptidoglycan synthesis? Give 2 examples of this.

Glycopeptides; (1) Bacitracin (2) Vancomycin

5

What is the mechanism of action of Sulfonamides and Trimethoprim? How do their exact mechanisms differ?

Block nucleotide synthesis by inhibiting FOLIC ACID SYNTHESIS (involved in DNA methylation); Sulfonamides inhibit PABA conversion to DHF; Trimethoprim inhibit DHF conversion to THF

6

Name the 2 antimicrobials that block nucleotide synthesis by inhibiting folic acid synthesis (involved in methylation).

(1) Sulfonamides (2) Trimethoprim

7

What is the mechanism of action of Fluoroquinolones? What are 2 examples of Fluoroquinolones?

Block DNA TOPOISOMERASES; Ciprofloxacin, Levofloxacin, etc.

8

Which 2 classes of antimicrobials blocks DNA topoisomerases? Give at least one example of each.

Fluoroquinolones - Cirofloxacin, Levofloxacin, etc.; Quinolone - Nalidixic acid

9

What is the mechanism of action of Rifampin?

Block mRNA SYNTHESIS

10

Which antimicrobial blocks mRNA synthesis (RNA polymerase)?

Rifampin

11

What is the mechanism of action of Metronidazole?

DAMAGE DNA

12

Which antimicrobial damages DNA?

Metronidazole

13

What is the mechanism of action of the following antimicrobials: Chloramphenicol, macrolides, clindamycin, streptogramins (quinupristin, dalfopristin), linezolid?

Block protein synthesis at 50S RIBOSOMAL SUBUNIT

14

Name 5 antimicrobials that block protein synthesis at 50S ribosomal subunit.

(1) Chloramphenicol (2) Macrolides (3) Clindamycin (4) Streptogramins (quinupristin, dalfopristin) (5) Linezolid

15

What is the mechanism of action of Aminoglycosides and Tetracyclines?

Block protein synthesis at 30S RIBOSOMAL SUBUNIT

16

Name the 2 antimicrobials that block protein synthesis at 30S ribosomal subunit.

(1) Aminoglycosides (2) Tetracyclines

17

What is the mechanism of action of Sulfonamides? What are 3 examples of Sulfonamides?

FOLIC ACID SYNTHESIS (DNA methylation) - Inhibit conversion of PABA to DHF; (1) Sulfamethoxazole (2) Sulfisoxazole (3) Sulfadiazine

18

What is the mechanism of action of macrolides? Give 3 examples of macrolides?

Block protein synthesis at 50S subunit; (1) Azithromycin (2) Clarithromycin (3) Erythromycin

19

What is the mechanism of action of streptogramins? Give 2 examples of streptogramins?

Block protein synthesis at 50S subunit; (1) Quinupristin (2) Dalfopristin

20

What is the mechanism of Aminoglycosides? Give 5 examples.

Block protein synthesis at 30S subunit; (1) Genatmicin (2) Neomycin (3) Amikacin (4) Tobramycin (5) Streptomycin

21

What is the mechanism of Tetracyclines? Give 3 examples.

Block protein synthesis at 30S subunit; (1) Tetracycline (2) Doxycycline (3) Minocycline

22

What is the mechanism of action of penicillinase-sensitive penicillins? What are 4 examples of such drugs?

Inhibit cell wall synthesis by blocking peptidoglycan cross-linking; (1) Penicillin G (2) Penicillin V (3) Ampicillin (4) Amoxicillin

23

What is the mechanism of action of penicillinase-resistant penicillins? What are 3 examples of such drugs?

Inhibit cell wall synthesis by blocking peptidoglycan cross-linking; (1) Oxacillin (2) Nafcillin (3) Dicloxacillin

24

What is the mechanism of action of antipseudomonals? What are 2 examples of such drugs?

Inhibit cell wall synthesis by blocking peptidoglycan cross-linking; (1) Ticarcillin (2) Piperacillin

25

What is the mechanism of action of cephalosporins (I-V)? What are 5 examples (one from each generation) of such drugs?

Inhibit cell wall synthesis by blocking peptidoglycan cross-linking; (1) 1st - Cephazolin, etc. (2) 2nd - Cefoxitin, etc. (3) 3rd - Ceftriaxone, etc. (4) Cefipime (5) Ceftaroline

26

What is the mechanism of action of carbapenems? What are 4 examples of such drugs?

Inhibit cell wall synthesis by blocking peptidoglycan cross-linking; (1) Imipenem (2) Meropenem (3) Ertapenem (4) Doripenem

27

What is the mechanism of action of monobactams? What is an example of such a drug?

Inhibit cell wall synthesis by blocking peptidoglycan cross-linking; Aztreonam

Decks in FA - Microbiology Class (43):