Micro Final Details

Question 1

Action of the diptheria and pseudomonas exotoxin A

Answer 1

Robosylate and inactivate EF-2 (AB-toxin)

Question 2

Action of pertussis toxin

Answer 2

Inactivated Gi–> increased cAMP

Impairs phagocytosis

Question 3

Cleaves snare proteins, inhibiting the release of neurotransmitters

Answer 3

Botlinum (prevent Ach release) and tetnus toxin (prevents GABA relase)

Question 4

Phospholipase that degrades cell membranes

Answer 4

C. perfringings Alpha Toxin

Question 5

mechanism of streptolysin O toxin

Answer 5

Lyses RBC

Question 6

Approximate MHC-II and T-cell receptors resulting in overwhelming release of INF-y and IL-2

Answer 6

S. pyogenes exotoxin A

S. aureus TSST-1

Question 7

ability to take up naked DNA from the environment and incorporate it into it’s own genome

Answer 7

Transformation

Question 8

Phage DNA incorportated into bacterial chromosome

Answer 8

Generalized tranduction

Question 9

Bacterial DNA accidentally incorporated into viral genome when it is excized

Answer 9

Specialized transduction

Question 10

G (+) Rods

Answer 10

Clostridium (anaerobe) (Cant Breath Air)

Corynebacterium

Listeria

Bacillus (aerobe) (Nagging Pests Must Breath)

Mycobacterium (acid fast)

Question 11

Binds Fc of IgG preventing complement formation

Answer 11

S. aureus

Protein A

Question 12

Lancet shaped diplococci with an IgA protease

Answer 12

S. pneumonia

Optochin sensitive

Question 13

G(+) rods with metachromatic granules

Answer 13

C. diptheriae

Question 14

Location of GABA inhibition by tetanus toxin

Answer 14

Inhibits SNAREs in the **Renshaw cells **of the GABAercic

neurons of the spinal cord

Question 15

Drug most commonly responsible for psuedomembranous colitis

Answer 15

Clindamycin and ampicillin

Question 16

Tumbling G(+) rod

Tx?

Answer 16

Listeria

Ampicillin

Question 17

Primary TB

Answer 17

Gohn focus (mid zone)

Hilar lymphadenopathy

–>Gohn complex

Question 18

2’ TB

Answer 18

Fibrocaseous necrotic lesion in upper lobes

Question 19

Two virulence factors of mycobacterium

Answer 19

Cord Factor: Inhibits macrophage matuation and induces TNF-alpha release

Sulfatide: Surface glycolipid which **inhibits lysosomal fusion **(reason why they can live inside macrophages)

Question 20

Leprosy infection with poor Th1 response?

Strong Th1 response?

Answer 20

Poor Th1: Lepromatous–> diffuse and communicable

Stong Th1: Tuberculoid: hypoesthtic nodues and hairless plaques

Question 21

G(-) Rod, Lactose nonfrementer, Oxidase (-)

Answer 21

Shigella

Salmonella

Proteus

Question 22

Culture difference between salmonella and shigella?

Answer 22

Salmonella–> motile H2S (+)

Shigella–> NON-motile H2S (-)

Question 23

G(-) Rod lactose fermenters

Answer 23

E. coli

Klebsiella

Question 24

Culture difference between klebsiella and E.coli

Answer 24

E. coli Indole (+)

Klebsiella Indole (-)

Question 25

Vaccine for this bug contains capsular polysaccharide (polyribosylribitol phosphate) conjucated to diptheria toxoid

Answer 25

H. influensza

Question 26

E. coli infection that is fecal leukocyte (+)

Answer 26

EIEC

Question 27

Bloody diarrhea and sorbitol non-fermenter

Answer 27

EHEC (O157:H7)

Question 28

rose spots on abdomen, fever and diarrhea

Answer 28

Typhoid fever Salmonella typhi

Question 29

Spirochete visualized on giesma of wright stain

Answer 29

Borellia | (Treponema is too small)

Question 30

Obligate intracellular organism that needs CoA and NAD+

Answer 30

Rickettsia sp.

Question 31

Centrifugal rash sparing the palms and soles

Answer 31

R. prowazekii--\> enpidemic typhus--\> human louse

Question 32

monocytes with berry-like inclusions

Answer 32

Ehlichiosis

Question 33

Cell wall lacking muramic acid

Answer 33

Chlamydia

Question 34

Follicular conjuctivits chlamydia types

Answer 34

A, B, C Causes blindiness in africa **A**frican **B**lindness **C**hlamydia

Question 35

Types of chlmydia that cause PID and Urethritis

Answer 35

types D-K Sexually transmitted...D-K...Think about it.

Question 36

Lymphgrnauloma venereum

Answer 36

Painful lyphadenitis and ulceration Chlamydia L1, L2 and L3

Question 37

Anemia with pneumonia

Answer 37

M. pneumoniae Cold agglutinins--\> IgM binds to RBC in periphery--\> lysed in spleen Anemia resolves wheni infection is Tx'ed