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Flashcards in Micro - Viruses Deck (108)
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1

DNA viruses - 3 rules of thumb

all dsDNA (except parvovirus, which is ss)

all linear (except papilloma, polyoma (circular, supercoiled), and hepadna- (circular, incomplete))

all non-enveloped (except Herpes-, Hepadna-, which are enveloped)

2

Herpesviruses - name all

HSV1 (oral)
HSV2 (genital)
HSV3 (VZV)
HSV4 (EBV)
HSV5 (CMV)
HSV6 (Roseola)
HSV8 (Kaposi)

dsDNA, linear, enveloped

3

herpesvirus that causes Roseola

HSV6
dsDNA, linear, enveloped

4

herpesvirus that causes VZV

HSV3
dsDNA, linear, enveloped

5

herpesvirus that causes EBV

HSV4
dsDNA, linear, enveloped

6

herpesvirus that causes Kaposi

HSV8
dsDNA, linear, enveloped

7

herpesvirus that causes CMV

HSV5
dsDNA, linear, enveloped

8

herpesvirus that causes oral lesions

HSV1
dsDNA, linear, enveloped

9

herpesvirus that causes genital lesions

HSV2
dsDNA, linear, enveloped

10

herpesvirus features

Enveloped, dsDNA, linear

11

hepaDNAvirus - examples + features

HBV - enveloped, partially dsDNA and circular

12

Adenovirus - features

dsDNA, linear, non-enveloped

13

parvovirus - examples + features

Parvo B19

no envelope, ssDNA and linear (smallest DNA virus)

14

papillomavirus - examples + features

HPV

no envelope, dsDNA and circular

15

Polyomavirus - examples + features

JC virus
BK virus

no envelope, dsDNA and circular

16

Poxvirus - examples + features

Smallpox
Cowpox
Molluscum contagiosum

enveloped, dsDNA and linear (largest DNA virus)

17

HSV1 - clinical features (transmission, presentation, treatment)

transmission: respiratory droplets, saliva

ORAL (some genital) lesions - swollen gums w/ ulcerative lesions, enlarged tender CERVICAL LN

temporal lobe encephalitis (cowdry type A inclusion)

keratoconjunctivitis

treatment: acyclovir


dsDNA, linear, enveloped

18

HSV1 - where does it establish latency in?

trigeminal ganglia

dsDNA, linear, enveloped

19

HSV2 - clinical features (transmission, presentation, treatment)

sex, perinatally

GENITAL (some oral) lesions

dsDNA, linear, enveloped

20

HSV3 - clinical features (transmission, presentation, treatment)

respiratory secretions

chicken pox (begins on trunk and spreads to face and extremities)

shingles (post-herpetic neuralgia)

both can cause encephalitis, pneumonia

dsDNA, linear, enveloped

21

HSV3 - where does it establish latency in?

DRG or CNV ganglia

dsDNA, linear, enveloped

22

HSV4 - clinical features (transmission, presentation, diagnosis)

EBV

respiratory secretions, saliva

mono (profound fatigue, myalgias, fever, posterior cervical lymphadenopathy, hepatosplenomeagly, sore throat)

Infects B cells -> cause atypical CD8 T cells ""Downey Cells

Monospot test (+) - heterophile antibodies that agglutinate sheep RBC

dsDNA, linear, enveloped

23

HSV4 causes two types of malignancies in two different populations

Hodgkin lymphoma, Burkitt lymphoma (Africa, involves jaw)

Nasopharyngeal carcinoma (Japan, China, involves nostrils, pharynx, maxillary sinuses)"

dsDNA, linear, enveloped

24

What is the monospot test used for?

distinguish between CMV and EBV, both can cause mono-like sx (profound fatigue, myalgias, fever, posterior cervical lymphadenopathy, hepatosplenomeagly, sore throat)


EBV/HSV4 = Monospot test (+) heterophile antibodies agglutinate sheep RBC

CMV/HSV5 = Monospot test (-) heterophile antibodies do not agglutinate sheep RBC

25

HSV5 - clinical features (transmission, presentation, diagnosis)

CMV

- transmission: sex, organ transplants

- AIDs CD4

26

where does CMV establish latency in?

mononuclear cells - see Owl eye inclusions

dsDNA, linear, enveloped

27

HSV6 - clinical features (transmission, presentation, diagnosis)

Roseola

transmitted via saliva

high fevers followed by diffuse macular rash, can cause febrile seizures; affects infants

dsDNA, linear, enveloped

28

HSV8 - clinical features (transmission, presentation, diagnosis)

Kaposi

transmitted via sex; common in HIV, transplant patients

endothelial cell neoplasm -> violaceous, flat nodular skin lesions

dsDNA, linear, enveloped

29

Adenovirus - clinical features (transmission, presentation, diagnosis)

pharyngitis, sore throat, pink eye (conjunctivitis) pneumonia, acute hemorrhagic cystitis

occurs in small outbreaks among individuals living together in close quarters (military barracks, camp dorms)

ø treatment

dsDNA, linear, non-enveloped

30

Parvovirus B19 - clinical picture in fetus, children, adults, and sickle cell patients?

fetus: hydrops fetalis

children: slapped cheek rash that spreads to the rest of the body

adults: anemia + RA-like sx

Sickle cell dz: aplastic anemia

ssDNA, linear, non-enveloped