Microbiology Chapter 14 Flashcards Preview

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Flashcards in Microbiology Chapter 14 Deck (24):
1

A category of immune response and first line of defense

Innate/Nonspecific

2

A defense a person is born with. It is nonspecific (protects against many different infections) and act immediately

Innate/Nonspecific

3

Examples of Non-specific Immunity

1. Barriers
2. Inflammation
3. Phagocytosis
4. Interferon
5. Complement

4

Are involved in both innate and adaptive immunity

White Blood Cells (WBCs)

5

Horse shoe or polymorphic nuclei.
It is present in high numbers in blood and tissue. It Phagocytizes (ingests) bacteria - granules are digestive enzymes. IT IS FIRST TO ARRIVE DURING AN IMMUNE RESPONSE (inflammation)

Neutrophils

6

Bilobed nuclei. Present in the bone marrow and spleen. Attach and destroy ekaryotic pathogens. Associated with inflammation and allergies.

Eosinophils

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Constricted nuclei. Present in low in number in the body. Function is similar to eosinophils. Has Mast Cells which are tissue cells with similar function to basophils.

Basophils

8

2 types of Agranulocytes/Mononuclear cells

Lymphocytes & Monocytes

9

Part of the Innate Immunity. Have Natural Killer cells which attack virus infected cells and cancer cells. (T-cells and B-cells)

Lymphocytes

10

Agranulocyte which differentiates into macrophages and dendritic cells in the tissues.

Monocytes

11

Ingest and digest large particles (bacteria), process foreign molecules and present them to lymphocytes, and secrete compounds that regulate immunity.

Phagocytes

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Where are white cells formed and respond to foreign molecules

Thymus and Spleen

13

Located in the upper left portion of the abdominal cavity. Filter for blood (traps pathogens and destroys pathogens through phagocytosis by macrophages). Adults can survive without spleen. Asplenic children are severely immunocompromised.

Spleen

14

Site for T-cells maturation. Embryo has two lobes in the pharyngeal region and has high activity (releases mature T cells) until puberty. In the adult, it gradually shrinks. It increases in size and effectiveness until puberty, then atrophies. Important for the formation of mature T-cells.

Thymus

15

Traps incoming microbes from food. Supply lymphocytes for antibody response. (EX// Appendix, Tonsils, Payer's Patches)

Gut-associated lymphoid tissue (MALT - also called GALT, gut associated lymphoid tissue.

16

Has five major symptoms:
1. Redness
2. Warmth
3. Swelling
4. Pain
5. Loss of Function

Inflammation

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Caused by cytokines

Fever

18

Proteins secreted by cells that activate other cells

Cytokines

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Caused by Pyrogens

Fever

20

Secreted cytokine

Interferon

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Consists of 26 blood proteins. Produced by liver hepatocytes, lymphocytes, and monocytes. It pathways, stages, and cascade reacts.

Complement

22

Activated by the presence of antibody bound to microbes

Classical Pathway

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Activated when a host serum protein binds a sugar (mannan) in the wall of fungi and other microbes.

Lectin Pathway

24

Activated when complement proteins bind to cell wall or surface components of microbes.

Alternative Pathway