Microbiology - Congenital and Neonatal Infections - Jennifer Moffat Flashcards Preview

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Flashcards in Microbiology - Congenital and Neonatal Infections - Jennifer Moffat Deck (16):
1

What is the definitive diagnosis of congenital infection of a neonate?

Definitive diagnosis: isolate pathogen from infant
Sample urine, saliva, cerebral spinal fluid (CSF), nasopharyngeal swabs, etc.

2

What is the most common congenital infection in this country?

CMV (Herpesvirus)

3

What is the classic triad of neonatal infection with toxoplasmosis?

Chorioretinitis;
Hydrocephalus;
Intracranial calcifications

**However, most affected infants are asymptomatic**

4

What is the diagnostic test for Toxo in infants?

IgM+;
Direct observation of cysts;
Do serology on mom and baby

5

What is the treatment of Toxo?

Pyrimethamine plus Sulfadiazine, Folinic acid, 1 year

6

Two thirds of infants infected with congenital syphilis are asymptomatic. What are the common manifestations if symptomatic?

Large, puffy placenta
Rhinitis
Hepatomegaly
Rash
Lymphadenopathy

7

What is the treatment of Toxo?

Treat mother and infant with penicillin G IV or IM for 10 days

8

Blueberry muffin rashes are seen in what two congenital infections?

Rubella;
CMV

9

What is the most common symptom of congenital rubella?

Hearing loss

10

How is congenital CMV diagnosed?

PCR on urine or blood
Culture virus from urine or saliva

11

What are the treatments for CMV?

Ganciclovir IV
Valganciclovir PO

12

What is the treatment of HSV in the infant?

IV acyclovir for infant

13

How is HSV infection prevented in the neonate?

C-section birth
Antiviral prophylaxis

14

What is the presentation of an infant with HSV?

Encephalitis, disseminated infection
Rare, devastating

15

How is GBS infection in neonates prevented?

Itrapartum Antibiotic Prophylaxis (IAP) of Pen G

16

What are the GBS classes?

Early onset - 0-7 days - pneumonia;
Late onset 7-89 days - CNS problems, meningitis;
Late, Late onset > 3 months - sepsis w/ foci in CNS