Microbiology of Lower Respiratory Infections Flashcards Preview

Respiratory 2 > Microbiology of Lower Respiratory Infections > Flashcards

Flashcards in Microbiology of Lower Respiratory Infections Deck (13):
1

Bronchiolitis

RSV - ssRNA neg...paramyxovirus

Outbrekas in winter

Low grade fever with prodrom URI

Wheezes, HYPOxia, hyperinflation...detect serologically

2

Intierstitial vs. typical in appearance

Typical - toxic, productive cough...fever...neutrophils

Atypical - mononuclears...nonproducitve cough...seems pretty well...gradual onset

3

Strep penumo

Lancet shaped diploccoci

Polysach capsule (important virulence factor...antigenic and antiphagocytic

PIli - enable attachment

IgA protease

Penumolysin - binds cholesterol and forms transmembrane pores sleading to cell death...inhibts cells of immune system

4

S. aureus

Coag positive beta hemolytic

Hematogenous spread in IVDU and IE

Acute lobae with abscess

5

Kleb and Hib

Gram neg rods

Think alcoholics or hospitalized (aspiration)

6

Legionella

Diarrhea and abdominal pain

Very high fever

Can lead to resp failure and shock

Fastidious gram neg rosd

Urine antigen

7

Myco pneumo

Earache with gradual headache, feve,r chills, dry cough

P1 protein binds sialic acid receptors...grow closely attached and inhibit ciliary action...desquamate...lack of cilia means decrease mucous clearance

8

Pesudo aeruginosa

LPS, pili, alginate and a flagellum help to attach

Exotoxin A inhibits elongation factor

CF, neutropenia, hospital

9

Coccidio

Enter throgh arthroconidia...germinate into spherules

10

Histo

YEast in macrophages

11

Blasto

Borad based buds...can have purulent sputum,

12

Aspergillus

Gliotoxin inhibits phagocytic killing

13

Pneumocystic jiroveci

HIV patients

CANNOT be cultured

Alveoli filled with desquamated alveolar cells, monocytes, etc, which produce foamy, honecycombed appearance