MIDTERM ANTIFUNGAL

Question 1

An infection caused
by a fungus is called a

Answer 1

mycosis

Question 2

fungus has a cell membrane that contains

Answer 2

ergosterol

Question 3

a fungus that is normally found on mucous membranes

Answer 3

Candida

Question 4

Treatment for candidiasis meningitis,

Answer 4

Fluconazole

Question 5

treatment for invasive aspergillosis

Answer 5

isavuconazonium

Question 6

treatment for blastomycosis

Answer 6

ITRACONAZOLE

Question 7

treatment for onchomycosis

Answer 7

terbinafine

Question 8

work by inhibiting glucan synthesis. Glucan is an enzyme
that is present in the fungal cell wall but not in human cell walls.

Answer 8

echinocandins

Question 9

treatemnt for candidemia infection of blood stream

Answer 9

Anidulafungin

Question 10

treatment for esophageal candidiasis

Answer 10

Micafungin

Question 11

antifungals that inhibit the synthesis of ergosterol

Answer 11

Posaconazole
voriconazole
isavuconazonium

Question 12

inhibits cytochrome P-450 2D6 (CYP2D6)
enzyme system

a better choice for patients who need to take drugs metabolized by the cytochrome

Answer 12

Terbinafine

Question 13

also available as a shampoo

Answer 13

Ketoconazole

Question 14

been associated with severe liver toxicity and are
contraindicated with liver failure.

Answer 14

Terbinafine
and isavuconazonium

Question 15

an herb frequently used to treat migraine headache and menstrual problems

Answer 15

ergot

Question 16

Drugs in this
class include anidulafungin (Eraxis), caspofungin (Cancidas), and
micafungin (Mycamine)

Answer 16

Echinocandin Antifungals

Question 17

l drugs work to alter the cell permeability of the fungus,
causing prevention of replication and fungal death

Answer 17

topical antifungal

Question 18

These drugs are not absorbed systemically and do not undergo metabolism or excretion in the body.

Answer 18

topical antifungal drugs

Question 19

work by inhibiting glucan synthesis

Answer 19

echinocandins

Question 20

an enzyme that is present in the fungal cell wall but not in human cell walls.

Answer 20

Glucan

Question 21

a very potent drug with many unpleasant adverse effects its use is reserved for progressive, potentially fatal infections

Answer 21

Amphotericin B

Question 22

a less toxic drug that alters the cell membrane of susceptible fungi

Answer 22

Flucytosine

Question 23

an older antifungal that acts in changing cell membrane permeability and causing cell death.

Answer 23

Griseofulvin

Question 24

Patients who receive amphotericin B should not take other nephrotoxic drugs such as____ because of the increased risk of
severe renal toxicity

Answer 24

nephrotoxic antibiotics or antineoplastics, cyclosporine, or corticosteroids

Question 25

in topical forms. Fungi that cause these mycoses are called

Answer 25

dermatophytes

Question 26

can cause intense, local burning and irritation and should be discontinued if these conditions become severe.

Answer 26

Econazole

Question 27

stains skin and clothing bright purple; in addition, it is very toxic when absorbed

Answer 27

Gentian violet

Question 28

should not be used for longer than 4 weeks due to the risk of adverse effects and possible emergence of resistant strains o

Answer 28

Naftifine, oxiconazole, and sertaconazole

Question 29

should not be used for longer than 6 weeks due to the risk of adverse effects and possible emergence of resistant strains of fungi

Answer 29

Sulconazole

Question 30

must be applied with the supplied flow-through brush ANTIFUNGALapplicator

Answer 30

Efinaconazole