MISC - Cancer medicine Flashcards Preview

► Med Misc 43 > MISC - Cancer medicine > Flashcards

Flashcards in MISC - Cancer medicine Deck (14):
1

describe the biology of a cancer cell

•Transformation from a cell of origin
•Acquisition of invasive properties
•Activation of cellular proliferative signals
•Abrogation of cell cycle control
•Up-regulation of angiogenesis
•Further clonal evolution

Cancer may be:
- localised
- locally advanced
- metastatic

2

describe the principles of diagnosis and staging in cancer patients

Imaging and Pathology

3

describe the (3) principles of treating cancer patients

•Local therapies (e.g. breast lesion)
–Surgery
–Radiotherapy

•Systemic therapies (e.g. metastatic cancer)
–Chemotherapy
–Hormone therapy
–Immunotherapy
–Molecular therapy

•Clinical Trials

4

define the difference between treatment with curative intent and palliative intent

Curative intent for Curable cancers
- Tolerate significant toxicity (even mortality) for chemo etc

Palliative intent for incurable cancers. Emphasis on QOL.
- Toxicity not tolerated

5

Name (3) screenings for cancer

Pap smears, Mammography and Faecal occult blood

Ongoing controversies: prostate, lung

6

(2) general Prevention of cancer

Smoking cessation and Sun smart

7

Describe roles of adjuvant treatment

•Breast / Colon / Lung / Sarcomas
•Reduces the risk of local recurrence
•Reduces the risk of systemic recurrence
•Improves overall survival
•Finite therapy
•Large numbers of patients treated for some individuals to benefit
•Tolerate some toxicity

8

What is the molecular target in CML/GIST? Treatment?

Bcr-Abl

Rx: Glivec

9

What is the molecular target in LUNG cancer? Treatment?

Anti-EGFR

Rx: Iressa

10

What is the molecular target in COLON cancer? Treatment?

VEGFRi

Rx: Bevacizumab

11

What is the molecular target in RENAL cancer? Treatment?

VEGFRi

Rx: Sunitinib

12

What is the molecular target in BREAST cancer? Treatment?

Her-2

Rx: Herceptin

13

What is the molecular target in LYMPHOMA cancer? Treatment?

Anti-CD20

Rx: Mabthera

14

What is the molecular target in MELANOMA cancer? Treatment?

B-Rafi

Rx: Vemurafinib

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