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Flashcards in Misc. Pharm Deck (31):
1

Cyclobenzaprine Class

Centrally-acting muscle relaxant

2

Cyclobenzaprine MOA

related to TCAs
reduces tonic somatic motor activity

3

Cyclobenzaprine Indication

muscle spasm

4

Cyclobenzaprine SE

1. antichol effect
2. CNS depression
3. decreased serotonin reuptake
4. xerostomia

5

Cyclobenzaprine Contra

1.

6

Cyclobenzaprine dx-dx

1. increase anti-chol
2. ethanol
3. SSRI
4. Tramadol

7

Cyclobenzaprine Monitor

1. mental
2. serotonin syndrome
3. LFTs

8

Baclofen Class

Centrally-acting muscle relaxant

9

Baclofen MOA

Inhibits transmission of synaptic reflexes @SC level

10

Baclofen Indication

1. MS
2. spinal cord lesions

11

Baclofen SE

1. vertigo
2. psych dist.
3. slurred speech
4. ataxia

12

Baclofen dx-dx

1. increased opioids, benzos, htn-agents
2. increase ethanol, CNS depressants, TCAs
3. clindamycin
4. MAOIs

13

Baclofen Other

Avoid with St. Johns wort, valerian, Kava kava

14

Dantrolene Class

Peripherally-acting muscle relaxant

15

Dantrolene MOA

acts directly on skeletal muscle, inhibits Ca release

16

Dantrolene Indications

1. muscle spasticity due to CVA, CP, SC
2. malignant hyperthermia
3. neuroleptic malignant syndrome

17

Dantrolene SE

1. confusion
2. hepatites
3. photosensitivity
4. HF

18

Dantrolene Contra

1. liver disease
2. cardiac problems
3. COPD

19

Dantrolene dx-dx

1. ethanol
2. St. Johns Wort
3. Kava Kava

20

Dantrolene other

CYP3A4 substrate

21

Amitriptylene

Tricyclic Antidepressant

22

Amitriptylene MOA

Inhibits reuptake of serotonin, NE in CNS

23

Amitryptyline Indication

1. chronic pain
2. depression
3. diabetic neuropathy
4. migraine prophylaxis

24

Amitryptyline SE

1. anticholinergic sxs (urinary retention, tachycardia, hypotension, sedation)

25

Amitryptyline black box warning

SUICIDE RISK!

26

Amitriptyline Monitoring

1. Mental status
2. EKG if heart prob
3. SI
4. urinary retention
5. BP/HR

27

Pilocarpine Class

Cholinergic Agent

28

Pilocarpine MOA

agonist on muscarinic receptors that stimulates salivary secretion

29

Pilocarpine Indications

xerostomia from radiation or Sjorgens

30

Pilocarpine SE

1. dizziness
2. urinary freq
3. weakness
5. sweating

31

Pilocarpine Contra

1. hepatic impairment (child-pugh>10)
2. asthma
3. closed-glaucoma (increased IOP)
4. CVD
5. COPD
6. nephrolithiasis