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Unit 4 > Miscellaneous > Flashcards

Flashcards in Miscellaneous Deck (79)
1

What are the Gq coupled receptors?

HAVe 1 M&M
H1
alpha1
V1
M1 and M3

2

What are the 2 receptors on uterus, and what do they do?

Alpha 1--->contraction
Beta 2--->relaxation

3

MOA of amphetamine/cocaine/MDMA/TCA?

Amp--->increase release of all 3 (NE/DA/5HT)
MDMA--->increase release of 5HT (happy!)
Cocaine--->block reuptake of NE/DA
TCA--->block reuptake of NE/5HT

4

Side effects of digoxin?

M agonist including blurry yellow vision (Van Gogh?)
Arrhythmia

5

Which 2 antibiotics should not be given to children and why?

Fluoroquinolone and doxycycline
Because of side effects

6

What is buprenorphine and what is it used for?

Partial mu agonist
Combine with naloxone for heroin addiction

7

Which antidepressant drug work like cocaine? and what is it used?

Bupropion
Alternative to SSRI since no sexual dysfunction

8

MOA of trazodone? usage?

Block 5HT2a/alpha 1/H1
Insomnia/high dose for antidepressant

9

Which antidepressant is sometimes used for pt who needs to gain weight? and which SSRI is the only approved drug for bulimia?

Mirtazapine
Fluoxetine

10

Carve my heart in bits?

Common beta blockers used for heart failure
Carvedilol/metoprolol/bisoprolol

11

Which muscarinic toxicity caused by AChE inhibitor can not be reversed with atropine?

Muscle paralysis--->since it is mediated by Nm receptor and atropine only blocks M

12

How do "zosin" treat BPH?

Decrease tone of urinary sphincter

13

Difference between efficacy and potency?

Efficacy--->max effect a drug can produce regardless of dose
Potency--->amount of drug needed for a given effect (effect must be the same)

14

Toxicity of theophylline?

Tremor and seizure

15

Loop and thiazide would increase which hormone?

Aldosterone--->and that's why you get hypokalemia and alkalosis with them

16

Dont use class 4 antiarrhythmia in what pts

HF--->it makes it worse

17

Effect of increasing atropine dosage?

decrease secretion--->mydriasis and cycloplegia--->hyperthermia--->tachy--->urinary retention--->hallucination

18

What would cause accommodation of near vision?

M agonist

19

Stimulate what receptor would cause prostate contraction?

Alpha 1

20

Epi can be used for ___ but NE can not be used for

Asthma (because of beta 2)

21

MOA of yohimbine? usage?

Alpha 2 antagonist--->postural HoTN and male impotence

22

What kind of beta blockers block renin release?

Beta 1 selective

23

Which 2 beta blockers have intrinsic sumpathomimetic activities (partial agonist)?

Pindolol and acebutolol

24

Which beta blocker cause the highest degree of sedation?

Propranolol

25

How does closed angle glaucoma occur?

Blockade of canal of schlemm

26

Nesiritide? used for?

BNP--->increase cGMP--->vasodilate
Acute decompensated HF

27

Can dobutamine be used in chronic CHF?

No

28

What metabolic disease can chronic steroid usage cause?

DM

29

What are doxepin and meclizine?

Doxepin--->TCA
Meclizine---->anti histamine/used for antiemetic for pregos

30

Dont use ___ for angina prophylaxis for DM pt

Beta blockers

31

Which lipid lowering drug shouldnt you give if a pt has liver disease? what is another name for it?

Niacin
Nicotinic acid

32

Which lipid lowering agent is a teratogen?

Statins

33

TCA would decrease the efficacy of which other antiHTN drug?

Guanethdine--->it uses Uptake 1 for transportation--->TCA blocks reuptake

34

What electrolyte abnormality worsen Li+ toxicity?

Hyponatremia

35

What enzyme does carbidopa inhibit?

dopa decarboxylase

36

Is valproic acid a CYP450 inhibitor or inducer?

Inhibitor

37

How does opioid affect the gallbladder?

Causes biliary colic (contraction of gallbladder)

38

What side effects would opioid user not be able to develop tolerance to

Constipation and miosis

39

What can be used for cocaine and amphetamine withdraw?

TCA (counter depression)

40

Which 2 doxycycline are excreted in feces?

Mino and doxycycline

41

Which macrolide can you use for pregnant women?

Erythromycin

42

Side effect of foscarnet? Ribavirin?

Electrolyte abnormalities--->hypokalemia/hypocalemia
Teratogen

43

MOA of ergotamine?

Alpha 1 and 5HT2 partial agonist

44

Carbamazapine and phenytoin both cause?

Aplastic anemia

45

If the pt is allergic to bactrium, which DM drug cant you give?

Sulfonylurea (sulfa allergy)

46

Which migraine drug can cause HTN crisis?

Triptans

47

What can diazoxide used for?

HTN crisis and hyperinsulinism

48

How does steroid cause osteoporosis?

Increase bone resorption and decrease bone formation
Decrease Ca absorption and increase Ca excretion

49

Which macrolide does not have CYP450 inhibition effect?

Azithromycin

50

What electrolyte abnormalities do succinycholine cause? and should be avoided to use in ___ pt

Hyper Ca and hyper K
Burn

51

Side effect of sirolimus?

Hyperlipidemia/pancytopenia/NOT renal toxic

52

If a pt is allergic to bactrim, what diuretics cannot be given? and what else?

Loop/thiazide/carbonic anhydrase inhibitor besides erthranyic acid
Celeoxib

53

What are the 2 special beta blockers? usage?

Carvedilol and labetalol
HTN crisis and pheochromocytoma

54

Which 2 beta blockers should not be given to angina pt?

Pindolol and acebutolol

55

What does demeclocycline cause?

nephrogenic DI

56

Which NSAIDs shouldnt you give to a gouty pt?

Aspirin

57

DOC for acute gout attack?

Indomethacin

58

What 2 drugs displace warfarin?

Aspirin and phenytoin

59

Which anticoagulant is used for pregos?

Xabans

60

Streptokinase is used with __ to reduce reinfarction and does not cause much more bleeding

Aspirin

61

cAMP increase or reduce platelet aggregation?

Decrease

62

Which 2 DM drug increase peripheral glucose uptake?

Metformin and glitazones

63

Take warfarin will increase or decrease your INR?

Increase (INR is how long it takes for your blood to clot)

64

Anti CCP antibodies?

RA

65

Which diuretic cannot be used for crush injury pt?

K sparing diuretics
Crush injury---->myeglobuinemia-->high potassium
K sparing diuretics cause high potassium--->combination is bad

66

Which anticoagulant has neutropenia as side effect?

Ticlopidine

67

Affect of anabolic steroids?

Increase EPO--->increase Hb and RBCs

68

Uterine bleed and acne can be treated with?

estrogen replacement

69

Which progesterone analog is not androgenic and anti estrogenic

Desogestrel

70

Effect of iodide on hyperthyroidism?

Inhibit T4 release from the thyroid

71

What is the synthetic version of somatropin?

Somatrem

72

What drugs are used to treat steroid induced osteoporosis?

Dronates

73

What does mycophenolate inhibit?

Inosine monophosphate dehydrogenase

74

Dronabinol?

Increase appetite during chemo therapy

75

Drugs used for stable angina? can you used beta blockers for vasospasm?

Nitrates/Ca channel blockers/beta blockers
No

76

Drugs that decrease mortality for stable angina pt

Beta blocker/nitroglycerin/aspirin

77

DOC for raynaud?

Nifedipine

78

Ranolazine? side effect?

Block Na current flow in the heart
Torsades

79

What do PDE3 and 5 break down?

PDE3--->cAMP
cAMP--->phosphorylation of MLCK--->SM relaxation
PDE5--->cGMP
cGMP--->PKG--->dephosphorylation of MLC--->SM relaxation