Module 11

Question 1

Which of the following inhibits CYP3A4?
 A. Grapefruit Juice
 B. St. John's wort
 C. Rifampin
 D. Phenobarbital

Answer 1

A. Grapefruit Juice

Question 2

What occurs when a local anaesthetic is administered with epinephrine?
A. The metabolism of the local anaesthetic is inhibited therefore providing greater local effect.
B. The metabolism of the local anaesthetic is induced therefore the patient may experience pain.
C. The blood vessels will vasoconstrict, decreasing the absorption of the anaesthetic.
D. The blood vessels will dilate, increasing the absorption of the anaesthetic.

Answer 2

C. The blood vessels will vasoconstrict, decreasing the absorption of the anaesthetic.

Question 3

At what site in the body does the interaction between probenecid and penicillin occur?
 A. Glomerulus
 B. Liver
 C. Proximal Tubule
 D. Distal Tubule

Answer 3

C. Proximal Tubule

Question 4

The interaction of disulfiram and alcohol is an example of which type of drug interaction?
 A. Pharmacodynamic
 B. Unique response
 C. Direct physical interaction
 D. Combined toxicity

Answer 4

B. Unique response

Question 5

What type of interaction occurs when diazepam is mixed with furosemide?
 A. Direct physical interaction
 B. Pharmacokinetic interaction
 C. Pharmacodynamic interaction
 D. Combined toxicity

Answer 5

A. Direct physical interaction

Question 6

Which of the following must a patient taking an MAO inhibitor avoid from their diet?
 A. Grapefruit juice
 B. A turkey sandwich with mustard
 C. A sausage with sauerkraut
 D. All must be avoided

Answer 6

C. A sausage with sauerkraut

Question 7

Which of the following may occur as a result of drug interactions?
 A. Increased drug effects
 B. Decreased drug effects
 C. A new drug related effect
 D. All may occur

Answer 7

D. All may occur

Question 8

Which patient is likely to experience the greatest degree of CYP induction?
A. A man who smokes on weekends when he’s out with friends
B. A man who drinks grapefruit juice with every meal
C. A women taking omeprazole to control gastric acid secretion
D. A chronic marijuana smoker

Answer 8

D. A chronic marijuana smoker

Question 9

Which patient group is most likely to experience a drug interaction?
 A. Adolescents
 B. Young adult
 C. The Elderly
 D. Newborn infants

Answer 9

C. The Elderly

Question 10

What occurs when a patient takes the anticoagulant clopidogrel and the gastric acid reducer omeprazole together?
A. They have excess anticoagulation and are less prone to cardiovascular events.
B. They have inadequate anticoagulation and are more prone to cardiovascular events.
C. They have increased gastric acid secretion.
D. They have decreased gastric acid secretion.

Answer 10

B. They have inadequate anticoagulation and are more prone to cardiovascular events.