beta lactam 3 drug classes
penicillins
cephalosporins
carapenems
beta lactam MOA
inhibit cell wall synthesis
- bind to PBP -> inihibit transpeptidase
- > inhibition of cell wall synthesis
beta lactam AE
hypersensitivity
- severe: anaphylaxis
- other: hives, rash
beta lactam administration
bacteriocidal
time dependent
beta lactam precaution
renally eliminated
beta lactam education
resistance d/t b-lactamase
cross-reactivity possible
naturally occurring penicillins
penicillin G
penicillin G benzathine
penicillin G procaine
penicillin V
PCNase resistant penicillins
nafcillin
oxacillin
dicloxacillin
amino penicillins
ampicillin
ampicillin/sulbactam
amoxicillin
amoxicillin/cluvalanate
extended spectrum penicillins
piperacillin
piperacillin/tazobactam
ticarcillin
ticarcillin/clavulanate
PBP
penicillin binding proteins
Penicillin G/V use
gram + - strepococci gram - - neisseria spirochetes - T. pallidum cellulitis otitis media syphilis strep pneumococcal pneumonia gangrene oral abscess
B-lactamse resistant penicillins
cloxacillin
dicloxacillin
nafcillin
oxacillin
B-lactamase resistant penicillin spectrum of activity
gram +
- streptococci
- staphylococci
No enterococcus or gram - activity
B-lactamase side group
large side group prevents b-lactamase from cleaving B-lactam ring
aminopenicillin use
streptococcus enterococcus listeria inc. anaerobe coverage gram - - E. coli - H. influenza - K. pneumoniae
ampicillin/amoxicillin AE
hypersensitivity
GI effects
rare hematological AE
nonimmunologicial rash (MONO)
extended spectrum penicillins spectrum of activity
gram +
excellent gram - including pseudomonas aeruginosa
anaerobes
Do not cover atypical organisms
broadest spectrum among penicillins
pip/tazo (zosyn)
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Intro to Patho32
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Cell structure and function93
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cpt 4: cell injury, aging and death70
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chapter 24: body fluid homoeostasis49
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Chapter 5 structure and function of DNA25
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chapter 6 genetic and developmental disorders and module 1 study guide71
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chapters 13,14,1198
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chapter 954
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chapter 1025
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Module 536
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exam 158
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module 6 neuronal communication108
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spinal cord injury13
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brain injury44
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pain physiology58
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chapter 4571
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fetal genital development8
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female reproductive system52
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male reproductive system21
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alterations of sexual maturation65
-
disorders of male reproductive system27
-
breast13
-
STI15
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module 9 bone formation50
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module 9 joints18
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module 9 muscles25
-
module 9 musculoskeletal injuries93
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module 9 disorders of skeletal muscles, peds, aging40
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module 6 chapter 46; ear, eye, taste, smell103
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module 7 hormones34
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module 7 endocrine organs/glands23
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Module 7 endocrine dysfunction65
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heart anatomy28
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Cardiac excitability/electro16
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blood flow and innervation39
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module 10 blood pressure35
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module 10 HTN and disorders56
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module 10 shock26
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module 10 congenital heart defects22
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module 10 vavles20
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module 10 synch session11
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module 11 functional anatomy of resp. system25
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module 11 ventilation20
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module 11 mechanics of breathing46
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module 11 general concepts in altered pulmonary function41
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module 11 obstructive lung disease25
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module 11 restrictive lung disease55
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module 11 pediatric33
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module 11 acid base25
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module 12 renal anatomy39
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module 12 regulation22
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module 12 age related changes24
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module 12 intra-renal disorders38
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module 12 glomerular disorders / AKI19
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module 12 acute tubular necrosis and CKD29
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module 12 lower urinary tract47
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module 12 congenital disorders10
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module 12 lecture20
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Module 13 general anatomy37
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Module 13 secretion and absorption21
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module 13 digestion and motility13
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module 13 pancreas33
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Upper GI disorders53
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module 13 lower GI disorders21
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module 13 malabsorption26
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module 13 hepatitis49
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module 13 DM30
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module 13 GI cancers11
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module 13 lecture14
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module 11 oncology overview15
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module 11 oncology supportive care23
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module 12 principles of anti-microbial therapy21
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module 12 beta-lactams penicillin19
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module 12 beta-lactams cephalosporins15
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module 12 beta-lactams carbapenems8
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module 12 other cell wall-acting agents12
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module 12 sulfonamides and UTI meds22
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module 12 protein synthesis inhibitors23
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module 12 protein inhibitors: aminoglycosides, oxalodidinones12
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module 12 cell membrane acting agents9
