Module 13 Flashcards
Barb: Used to treat migraine headaches
Butalbital
Barb: Most immunoassays are designed to detect:
Secobarbital
Barb: Used to control seizures
Phenobarbital
One of the most important pharmacokinetic characteristics of barbiturates is their ability to:
Induce microsomal liver enzymes
Adjustment of the pH to approximately _______ and extraction with an immiscible organic solvent will cause the barbiturates to enter the organic layer.
5-7
To treat seizures, a phenobarbital concentration of _______ is consistent with a therapeutic concentration.
15-40 mcg/mL
Death following barbiturate intoxication is often due to:
Respiratory failure
The _______ barbiturates are used to induce surgical anesthesia:
Ultra short acting
This is the major inhibitory neurotransmitter in the brain.
GABA
GABA antagonist and benzodiazepine antidote.
Flumazenil
Benzodiazepines mediate their CNS depressant activity through this neurotransmitter:
GABA
Adjusting the pH to _______ allows extraction of benzodiazepines into an immiscible organic solvent.
9-10
Benzodiazepine especially effective in managing panic disorder.
Alprazolam
This benzodiazepine is relatively unstable in postmortem specimens due to bacterial and thermal degradation.
Clonazepam
Benzodiazepines belong to this category of drugs in a DRE evaluation.
CNS depressants
Used for the short term treatment of insomnia.
Temazepam
This benzodiazepine is thermally unstable.
Chlordiazepoxide
Benzo: Effective in managing acute ethanol withdrawal.
Diazepam
Benzo: Can be missed by several commercially available immunoassay screening tests.
Lorazepam
Clonazepam undergoes ______ to form 7-Aminoclonazepam.
Reduction
This drug is a derivative of imidazopyridine.
Zolpidem
Glutethimide is structurally similar to this barbiturate.
Phenobarbital
Name the 3 Z Drugs?
Zaleplon, Eszopiclone, Zolpidem
What 3 benzos have no active metabolites?
Lorazepam, Oxazepam, Estazolam
