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Flashcards in Module 2 Deck (234)
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31

Antagonist of Alpha 1 receptors

Prazosin

32

location:
- prominent in the heart
- salivary glands
- adipose tissue
- kidneys (promote renin secretion)
Mechanism of Action:
- involves Gs protein activation of adenylcyclase to increase cAMP concentration

Beta 1 Receptors

33

sites:
- predominate in smooth muscle of airways
- blood vessels of skeletal muscles
- GIT and bladder walls
Mechanism of Action:
- same as beta 1
- involves Gs protein activation of adenylyl cyclase to increase cAMP concentration

Beta 2 Receptors

34

Potentiates cholinergic effects

Parasympathomimetic Agents

35

Parasympathomimetic Agents that interact with muscarinic receptors imitating ACh

Pilocarpine

36

Parasympathomimetic Agents that interacts with nicotinic receptors mimic ACh

Nicotine

37

Parasympathomimetic Agents that inactivate or inhibits acetylcholinesterase

Neostigmine

38

Blocks cholinergic effects

Parasympatholytic Agents

39

Parasympatholytic Agents that inhibit active uptake of choline from the blood to the axon terminal

Hemicholine

40

Parasympatholytic Agents that inhibits ACh release from synaptic vesicles

Botulinum Toxin

41

Parasympatholytic Agents that competes with ACh at muscarinic receptor sites

Atropine, Homatropine, Scopolamine

42

Potentiates adrenergic effect

Sympathomimetic Agents

43

Sympathomimetic Agents that interact with alpha-receptors

Methoxamine, Phenylephrine

44

Sympathomimetic Agents that interacts with beta-receptors

Salbutamol (Β2), Isoproterenol (Β1= Β2)

45

Sympathomimetic Agents that cause release of NE from its storage vesicles

Ephedrine, Amphetamine

46

Sympathomimetic Agents that prevents reuptake of NE by the postganglionic fibers

Cocaine

47

Blocks adrenergic effects

Sympatholytic Agents

48

Sympatholytic Agents that inhibit diffusion of NE out of the vesicle

Resirpine

49

Sympatholytic Agents that inhibits or blocks NE release from storage vesicles

Guanethedine

50

Sympatholytic Agents that blocks effects of NE on adrenoreceptors

Phenoxybenzamine, where is this used? pheochromocytoma

51

Sympatholytic Agents that competes with NE at beta receptors

Propranolol

52

Drug that does NOT block effects on alpha receptors. It blocks beta-receptors nonselectively

Propranolol

53

Function of Muscles

- Movement
- Energy Storage

54

Types of Muscle

1. Skeletal
2. Cardiac
3. Smooth

55

- extremities, voluntary, striated multinucleated
a. Intrafusal: Muscle Spindle
b. Extrafusal: For Muscle Contraction
i. White/Fast-Twitch Fiber
ii. Red/Slow-Twitch Fiber

Skeletal Muscle

56

Contraction speed: Slow, prolonged
Myosin ATPase activity: Slow
Major ATP synthesis pathway: Aerobic/ Oxidative
SR Ca pumping capacity: Moderate (SERCA2)
Rate of fatigue: Slow

Type 1: Slow Oxidative (Red Muscle)

57

Fiber diameter: small
Oxidative Capacity: High
Glycolytic capacity: Moderate
Activities: Endurance
Location: Soleus, anti-gravity muscles of the back

Type 1: Slow Oxidative (Red Muscle)

58

Contraction speed: Fast
Myosin ATPase activity: Fast
Major ATP synthesis pathway: Glycolysis
SR Ca pumping capacity: High (SERCA1)
Rate of fatigue: Fast

Type IIB: Fast Glycolytic (White Muscle)

59

Fiber diameter: Larger (2x)
Oxidative Capacity: Low
Glycolytic capacity: High (rapid release)
Activities: Quickness, Power
Location: EOM

Type IIB: Fast Glycolytic (White Muscle)

60

- can be found in other animals
Contraction speed: Fast/ Intermediate
Myosin ATPase activity: Fast
Major ATP synthesis pathway: Aerobic/ Oxidative
SR Ca pumping capacity: High
Rate of fatigue: Intermediate

Type IIA: Fast Oxidative (Red to Pink)