Monoamine Oxidase Inhibitors Flashcards Preview

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Flashcards in Monoamine Oxidase Inhibitors Deck (41):
1

The normal role of monoamine oxidase in the body is:

Deactivating certain NT's

2

T/F Monoamine Oxidase exists in two types.

TRUE - A&B

3

Type A is predominant in the:

GI tract wall, deactivates 5HT & NE

4

Type B is predominant in the:

Brrrrrrraaaaaain. Deactivates Dopamine

5

Without the action of MAO, Neurotransmitters would:

Continue to exert their effects

6

MAOI's are effective in relieving depression by:

Blocking the normal deactivation of 5HT & NE, thus increasing the levels in synapse.

7

T/F MAOI's are well absorbed in the GI.

TRUE

8

MAO inhibition peaks in:

One Week

9

Therapeutic effect (like the rest of 'em)

2-4 Weeks

10

T/F Dosage of MAOI should be increased quickly.

FALSE - increased & decreased slowly.

11

Side fx of MAOI's include: (4)

Orthostatic Hypotension
Anticholinergic Effects
Anxiety & Agitation
Insomnia

12

There are two types of MAOI. They are:

Reversible
Irreversible

13

Irreversible MAOI's work by:

Binding permanently to the MAO molecules, destroying its function.

14

MAO enzyme can then only be returned with:

Synthesized MAO

15

Patients on Irreversible MAOI's must:

Adhere to STRICT DIET RESTRICTIONS

16

Patients on Irreversible MAOI's run a great risk of:

Hypertensive Crisis

17

Two types of Irreversible MAOI & Dosage:

Phenelzine 45-90
Tranylcypromine 30-60

18

The reversible MAOI's are also called:

Reversible Inhibitors of MAO-A (RIMA)

19

They are so called b/c...

Binding is NOT permanent, and inhibitor can be dislodged from MAO.

20

The big win for reversible MAOI's is that:

Dietary Restrictions are NOT REQUIRED

21

One reversible MAO & dosage:

Moclobemide 300-600mg

22

While the MAOI's may block deactivation of NT's they also have this effect:

Limit the amount of NE released @ synapse.

23

The ability of MAOI's to inhibit the release of NE leads to the creation of an:

Unused NE Reservoir

24

So if the balance is thrown off and the NE released we run the risk of:

Hypertension

25

Norepinephrine is a potent

Vasoconstrictor (Sympathomimetic)

26

The reservoir can be released by stimulation from:

Other sympathomimetics
(ie. stimulants, Rx & OTC)
Certain Foods in Diet

27

MAO-A is an important enzyme in the..

GI Tract

28

The role MAO-A plays isL

Deactivates Amines

29

These amines are typically termed:

Pressor Amines

30

Pressor Amines have the ability to:

Stiumlate sympathetic nervous system &
Raise blood pressure

31

Dietary sources of pressor amines...?

Tryamine (often in protein)

32

When we introduce a MAOI antidepressant, these amines are:

No longer deactivated & absorbed into blood stream.

33

The resulting high level of __________ stimulaties the release of _________ & can lead to ____________.

Tyramine
Norepinepherine
Hypertensive Crisis

34

To avoid the risk, pt must:

Avoid foods high in tyramine

35

T/F Once stopping meds pt can have a tyramine buffet.

FALSE - 2 weeks on diet following discontinue

36

Tyramine originates in foods from the:

Breakdown of amino acids (proteins)

37

This breakdown occurs in: fapss

Fermenting
Aging
Pickling
Smoking
Spoiling

38

MAOI mixed with other AD leads to..

Potentiation of anticholinergic fx
Serotonin Syndrome

39

Moclobimide is potentiated x2 by

Cimetidine

40

MAOI potentiate _________ leading to CNS depression.

Demerol

41

In addition to tyramine these drugs can Induce hypertensive crisis:

Sympathomimetics
-cold n fever remedies
-antihistamines decongestants
-diet and pep pills