Flashcards in Monoamine Oxidase Inhibitors Deck (41):
The normal role of monoamine oxidase in the body is:
Deactivating certain NT's
T/F Monoamine Oxidase exists in two types.
TRUE - A&B
Type A is predominant in the:
GI tract wall, deactivates 5HT & NE
Type B is predominant in the:
Brrrrrrraaaaaain. Deactivates Dopamine
Without the action of MAO, Neurotransmitters would:
Continue to exert their effects
MAOI's are effective in relieving depression by:
Blocking the normal deactivation of 5HT & NE, thus increasing the levels in synapse.
T/F MAOI's are well absorbed in the GI.
MAO inhibition peaks in:
Therapeutic effect (like the rest of 'em)
T/F Dosage of MAOI should be increased quickly.
FALSE - increased & decreased slowly.
Side fx of MAOI's include: (4)
Anxiety & Agitation
There are two types of MAOI. They are:
Irreversible MAOI's work by:
Binding permanently to the MAO molecules, destroying its function.
MAO enzyme can then only be returned with:
Patients on Irreversible MAOI's must:
Adhere to STRICT DIET RESTRICTIONS
Patients on Irreversible MAOI's run a great risk of:
Two types of Irreversible MAOI & Dosage:
The reversible MAOI's are also called:
Reversible Inhibitors of MAO-A (RIMA)
They are so called b/c...
Binding is NOT permanent, and inhibitor can be dislodged from MAO.
The big win for reversible MAOI's is that:
Dietary Restrictions are NOT REQUIRED
One reversible MAO & dosage:
While the MAOI's may block deactivation of NT's they also have this effect:
Limit the amount of NE released @ synapse.
The ability of MAOI's to inhibit the release of NE leads to the creation of an:
Unused NE Reservoir
So if the balance is thrown off and the NE released we run the risk of:
Norepinephrine is a potent
The reservoir can be released by stimulation from:
(ie. stimulants, Rx & OTC)
Certain Foods in Diet
MAO-A is an important enzyme in the..
The role MAO-A plays isL
These amines are typically termed:
Pressor Amines have the ability to:
Stiumlate sympathetic nervous system &
Raise blood pressure
Dietary sources of pressor amines...?
Tryamine (often in protein)
When we introduce a MAOI antidepressant, these amines are:
No longer deactivated & absorbed into blood stream.
The resulting high level of __________ stimulaties the release of _________ & can lead to ____________.
To avoid the risk, pt must:
Avoid foods high in tyramine
T/F Once stopping meds pt can have a tyramine buffet.
FALSE - 2 weeks on diet following discontinue
Tyramine originates in foods from the:
Breakdown of amino acids (proteins)
This breakdown occurs in: fapss
MAOI mixed with other AD leads to..
Potentiation of anticholinergic fx
Moclobimide is potentiated x2 by
MAOI potentiate _________ leading to CNS depression.