More neuropharm Flashcards Preview

MBB Block II > More neuropharm > Flashcards

Flashcards in More neuropharm Deck (16):
1

What does phenobarbital do?

bind to the barbiturate site on the GABA-A receptor and increase GABA activities by increasing length of time that the channel stays open

2

What does diazepam do?

diazepam is a benzodiazepine. binds as an agonist at the BDZ site (gamma receptor) and increases receptor affinity for GABa

3

What are uses of benzodiazapines?

anxiety, hypnosis, seizures, muscle relaxation, anmesia. May also be used for alcohol withdrawal.

4

How are BDZs classified?

duration of action. (diazepam lasts 1-3 days)
alprazolam/Xanax and lorazepam is intermediate duration- 10-12 hr half life.

5

What is another use of lorazepam?

anti-seizure

6

What should be used in cases of BDZ overdose?

BDZ antagonists like flumazenil

7

What should I know about the pharmacokinetics of benzodiazepines?

may be given orally or parenterally
very lipid soluable, so may redistribute into body fat. hepatic metabolism, renal clearance.

8

Adverse effects of benzodiazepines?

somnolence, consusion, tremor, amnesia, esp. in elderly. respiratory suppression, CNS depression, hypotension, bradycardia. may develop tolerance and/or cross-tolerance (esp. with alcohol).

9

What is buspirone?

as efficacious as BDZs. Acts at 5-HT receptors. causes litte sedation but may cause tachycardia and GI upset

10

What is chloral hydrate?

mostly used as a hypnotic

11

How can propanolol be used for anxiety

block sympathetic symptoms. may be good for social phobia if antidepressants aren't warranted (stage fright)

12

What is propofol?

hypnotic sedative, but not an analgesic.

13

MOA of propofol?

beta subutin of GABA a receptor. stabilizes the activated state (increases length of opening?)

14

uses of propofol?

anesthetic, status epilepticus

15

Pharmacokinetics of propofol?

extraheptaic clearance. half-life in body is long, but wake-up is 10-30 mins after sustained sedation. good even in patients with cirrhosis or renal insufficiency.

16

What are limitations of propofol?

requires an ET tube. may cause bradycardia, hypotension ,arrhythmias, and is associated with malignant hyperthermia. reduces cerebral blood flow. careful with kids- more likely to cause cardiac collapse.