Motor Neuron Disease Flashcards

1
Q

Aetiologies?

A

Idiopathic
Viral
Familial

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Pathology?

A

Progressive destruction of the UMN and LMN in the motor cortex, spinal cord and peripheral nerves

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Signs and symptoms?

A

Four main patterns:
ALS - lateral cortocospinal tract and anterior horn signs
Hand small muscle wasting
Bulbar/psuedobulbar palsies
Primary lateral sclerosis - purely UMN signs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Investigations and findings?

A

Careful history and examination

MRI excludatory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Management?

A

Palliative - MDT based

Sodium channel blocker prolongs life slightly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Complications?

A

Prognosis bleak

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Epidemiology?

A

M > F, 3:2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly