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8501 Clin Med > MS 2 > Flashcards

Flashcards in MS 2 Deck (18):
1

A primary demyelinating disorder includes direct damage by:

inflammatory cells

2

A primary demyelinating disorder includes indirect damage by:

extracellular environment

3

With a primary demyelinating disorder, neurons become more susceptible to

apoptosis

4

Nerve recovery following myelin damage

after damage, nerve conduction properties can recover

5

Why are nerves able to recover following myelin damage?

redistribution of Na channels

6

MS is primarily a ______ inflammatory disorder

T cell mediated

7

It is hypothesized that preexisting autoreactive T cells are activated by:

- foreign microbes
- self-proteins
- microbial superantigens

8

What is overproduced with MS? (inflammatory)

cytokines

9

In MS, an excessive amount of _____ is released by lymphocytes and macrophages

glutamate

10

What is a plaque? Where are they formed?

focal abnormalities that spread through cerebral hemispheres

11

Main areas of plaque occurrence

- surrounding ventricles
- optic nerves
- brainstem

12

Acute lesions

- pink
- faint borders

13

Chronic lesions

- gray
- firm
- sharp edges

14

What are the main pathologic conditions of MS?

- inflammation
- demyelination
- axon loss

15

What is long term disability primarily caused by with MS?

- irreversible axon loss
- cell death

16

Where does apoptosis take place?

- OLIGODENDROCYTES
- neurons
- leukocytes

17

What happens to demyelinated axons with chronic lesions?

- undergo Wallerian degeneration along neuron tracts
- away from initial site of injury

*contributes to disability

18

Where do inflammatory changes often occur with MS?

in the perivascular space

Decks in 8501 Clin Med Class (102):