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Neurology > MS > Flashcards

Flashcards in MS Deck (20):
1

MS affects what part of the brain?

white matter and spinal cord
axons
near ventricles and optic nerve
cerebellum, brain stem, basal ganglia
*depending on what part of brain affects = sx

2

MS - cx?

unknown
suspicions of genetics

3

MS - imaging?

plaques (near ventricle and optic nerve)
*not diagnostic

4

MS - population?

20-30 yo
females
caucasian
northern latitudes

5

MS - sx?

blurred vision
numbness/tingling
balance
spasticity
bowel, bladder, sexual fxn changes
Uhthoff phenomenon
Lhermitte's sign

6

Uhthoff's phenomenon?

worsening sx after exposure of some out of norm temp (bath tub)

7

Lhermitte's sign?

tingling down back into limbs when flexing neck

8

Lesion?

pyramidal/cortitcospinal

9

MS - classification?

relapsing remitting
secondary progressive
primary progressive
progressive relapsing

10

Relapsing remitting?

episodic
never return to baseline
worse sx w/ every episode

11

Secondary progressive?

starts off as relapsing but turns into primary progressive (never getting better/not episodic)

12

Primary progressive?

not episodic - always getting worse

13

Progressive relapsing?

episodic and progressively getting worse

14

What is not typical of MS?

50 yo
cortical deficits (alexia, agraphia, apraxia, aphasia)
seizures
early dementia
rigidity (basal ganglia)

15

MS - dx?

CIS - lasts 24 hrs d/t inflammation/demylination
nothing definitive - clinical dx (but early dx = slows progression)

16

MS - PE/exams?

25 foot timed walk
9 hole peg (UMN)

17

MS - imaging?

MRI (even for baseline)
b/c if plaques are found 1st around - does not tell us when plaques were there - but if f/u is done then there is a timeline (plaques along ventricles over short pd of time = most likely MS though NOT diagnostic)

18

MS - CSF?

not needed unless MRI is not good enough
+protein, norm glucose
CSF oligoclonal banding
CSF IgG synthesis

19

MS - tx?

nothing - DMT (Dz modifying therapy)
-does not reverse sx, resuce acute MS relapses, slow dz
acute? - HD, short corticosteroids; plasma exchange
Beta interferons (pallative)
Vita D (doesn't hurt to give em; may reduce relapse if it works)
OT/PT (to make them more functional)

20

MS - what to watch out for?

immunization
depression