Flashcards in MS Deck (15):
Which condition is second only to trauma as a cause of disability in young people?
Name conditions which can mimic MS
Vitamin B12 deficiency, neurosarcoidosis, neuromyelitis optica, SLE (and other vasculitides)
Other conditions which can cause optic neuritis
Extensive cerebral metastases, CNS infection
Why does Scotland have a high incidence of MS?
Vitamin D deficiency through lack of sunlight & bad diet (no oily fish)
3 pathological stages of MS
plaque formation after incomplete healing
Describe the immune response in MS
T cell mediated immune response. A trigger disrupts the BBB, letting autoreactive myelin sensitive T cells attack oligodendrocytes.
Neck flexion causes parasthesia/tingling down spine due to plaques in the cervical spinal cord
Worsening of symptoms with an increased body temperature
MS relapses in pregnancy
Reduced releases in pregnancy, increased for a few months post delivery
Radiologically isolated syndrome
Incidental radiological evidence of CNS demyelination but symptomatic. ~60% get MS
Clinically isolated syndrome
Single episode with symptoms, no PMH, maybe normal MRI.
~50-85% get MS
Well defined, homogenous, ovoid contrast enhancing lesions in white matter. Especially in: corpus colosseum, periventricular, brain stem, cerebellar peduncles
presence or oligoclonal bands of IgG (increased IgG production in CNS by B cells). sensitive, not specific
EP study findings
reduced conduction velocity