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Flashcards in MS Deck (15):
1

Which condition is second only to trauma as a cause of disability in young people?

Multiple Sclerosis

2

Name conditions which can mimic MS

Vitamin B12 deficiency, neurosarcoidosis, neuromyelitis optica, SLE (and other vasculitides)

3

Other conditions which can cause optic neuritis

Extensive cerebral metastases, CNS infection

4

Why does Scotland have a high incidence of MS?

Vitamin D deficiency through lack of sunlight & bad diet (no oily fish)

5

3 pathological stages of MS

demyelination,
acute inflammation,
plaque formation after incomplete healing

6

Describe the immune response in MS

T cell mediated immune response. A trigger disrupts the BBB, letting autoreactive myelin sensitive T cells attack oligodendrocytes.

7

Lhermitte’s sign

Neck flexion causes parasthesia/tingling down spine due to plaques in the cervical spinal cord

8

Uhthoff’s phenomenon

Worsening of symptoms with an increased body temperature

9

MS relapses in pregnancy

Reduced releases in pregnancy, increased for a few months post delivery

10

Radiologically isolated syndrome

Incidental radiological evidence of CNS demyelination but symptomatic. ~60% get MS

11

Clinically isolated syndrome

Single episode with symptoms, no PMH, maybe normal MRI.
~50-85% get MS

12

MRI findings

Well defined, homogenous, ovoid contrast enhancing lesions in white matter. Especially in: corpus colosseum, periventricular, brain stem, cerebellar peduncles

13

CSF findings

presence or oligoclonal bands of IgG (increased IgG production in CNS by B cells). sensitive, not specific

14

EP study findings

reduced conduction velocity

15

Acute relapse management

3-5 days of methylprednisolone (P.O. if moderate, IV if severe)