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Flashcards in MS Drugs Deck (19):
1

Slow creation of new hyperintense lesions on T2 flair

Interferon Beta

2

Can develop antibodies to these and they will no longer work (most often occurs in smokers)

Interferon Beta

3

All have flu-like sxs as side effects and injection site rxs

Interferon Beta

4

Acts in inflammatory process at MHC

Glatiramer Acetate

5

Daily subcutaneous injection.
Fewer SEs than interferon betas, but less effective in aggressive disease

Glatiramer Acetate

6

Injection site rxs, lipoatrophy, injection related chest tightness, dyspnea, and flushing

Glatiramer Acetate

7

Binds sphingosine 1 phosphate and sequesters lymphocytes in LNs

Gilenya

8

Significant bradycardia and hypotension at first dose

Gilenya

9

Can result in teratogenicity

Teriflunomide

10

If pregnant, remove teriflunomide from system with

cholestyramine

11

Limits enzyme in pyrimidine synthesis pathway in lymphocytes.
Blocks proliferation of activated T and B cells responsible for inflammation in MS

Teriflunomide

12

Alopecia, risk of hepatotoxicity

Teriflunomide

13

Doesn't affect surveillance immune system

Teriflunomide

14

Activates Nrf2 pathway involved in cellular response to oxidation stress

Dimethyl fumarate

15

IV based infusion
Human monoclonal antibody targets alpha-4 ingetrin at BBB

Natalizumab

16

Blocks lymphocytes from entering brain

Natalizumab

17

Used for patients with very aggressive disease who have failed lower risk therapies

Natalizumab

18

Very risky. Increased risk for PML

Natalizumab

19

Decreases T cell migration and decreases # of clinical exacerbations

Interferon Beta