MS lectures 1-2 Flashcards Preview

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Flashcards in MS lectures 1-2 Deck (17):
1

19 days

Somites in mature gastrula

2

6 weeks..

Mesenchymal condensation for appendicular skeleton bones

3

10 weeks..

Primary centers of ossification expand in diaphyses

4

31-32 days..

Limb buds develop

5

4th

Organogensis

6

Meromelia

absence of part of a limb ( disrupted Fgf)

7

Amelia

absence of an entire limb (loss of Fgf signaling)

8

Phocomelia

Short, poorly formed limb ( Partial loss of Fgf, Hox disruption)

9

Ectrodactyly

Absence of fingers or toes (Hox 13, late loss of Fgf signaling)

10

Polydactyly

Extra digits (disruption of Shh pathway)

11

Syndactyly

Fusion of digits (Bmp disruption)

12

Adactyly

Absence of digits (late loss of Fgf)

13

Dorsal ectoderm expresses ________ and ________ which induces ________.

Wnt-7a; radical fringe; Lmx-1

14

Ventral ectoderm expresses __________, which inhibits Wnt7a and r-Fng.

Engrailed-1

15

______ important for digit formation.

AER

16

Digit identity is patterned by ________.

Shh

17

______ is critical for segment identity/ acts as switches and control pattern formation during development.

Homeotic genes (Hox)