MSK and SKin

Question 1

LEMS has _muscle weakness (first) + _ symptom and _ with exercise(as opposed to MG)

Answer 1

LEMS has proximal muscle weakness (first) + autonomic symtoms and normalizes with exercise(as opposed to MG)

Question 2

Pathogenesis of RA is via macrophage _= eternercept targets.

Answer 2

Pathogenesis of RA is via macrophage TNF(a)= eternercept targets.

Question 3

Goodpastures vrs contact dermatis = type _ vrs type _

Answer 3

Wound Healing: contracture due to inc MMP + myofibroblasts activity

Question 4

Ant. view of knee: ACL/PCL attach _ + _ femur condyle/

Answer 4

Ant. view of knee: ACL/PCL attach ant + lat femur condyle/ post + medial femur condyle

Question 5

obturator artery/ medial circumflex important for child/adult because /

Answer 5

obturator artery/ medial circumflex important for child/adult because epiphyseal growth plate in head /main blood supply to femoral neck

Question 6

Paget disease labs: all normal except _

Answer 6

Paget disease: all normal except Alk phosphotase

Question 7

Drug induced lupus eythematosus(DILE): _antibodies more specific than anti-dsDNA -> presents in slow acetylators( procainamide)

Answer 7

Drug induced lupus eythematosus(DILE): Anti-histone antibodies more specific than anti-dsDNA -> presents in slow acetylators( procainamide)

Question 8

Dermatomyositis has _ inflammation

Answer 8

Dermatomyositis has perimysial inflammation(because skin affected too)

Question 9

anti-_ for crest vrs dna_ for SCL

Answer 9

anti-centromere( c for crest vrs dna topoisomerase for SCL)

Question 10

29. Alkaptouria vrs homocyteinuria=

Answer 10

29. Alkaptouria/ homocyteinuria= homogenistic oxidase def/ methinine or cytathione syntase problem -> systemic symptoms

Question 11

IL-1 and TNF-A are inflammatory cytokines(cox-_ is induced l):
celeximab ( mech selectivity inhibits cox-_)

infliximab inhib _

Answer 11

IL-1 and TNF-A are inflammatory cytokines(cox-2 is induced vrs cox-1 constituitional): celeximab ( mech selectivity inhibits cox-2)
infliximab inhib TNFa

Question 12

Hematogenous osteomyelitis: adults/children = where -> sequestrum _ by involcrum (?)

Vertebral osteomyeliitis: recent _ predispose , _ of spine is best for imagining

Analgesics and close follow up for _issues

Answer 12

Hematogenous osteomyelitis: adults/children = vetebral/metaphysis -> sequestrum surrounded by involcrum = necrotic bone + overlying bone

Vertebral osteomyeliitis: recent endocarditis/bacteremia( staph) , MRI of spine is best
Analgesics and close follow up for MSK issues

Question 13

_ :systemic sysmptoms + cervical _laxation( spares hips and lubosacral joints) + anti CCRP

Answer 13

RA: systemic sysmptoms + cervical sublaxation( spares hips and lubosacral joints) + anti CCRP

Question 14

Only _ is intracellular

Answer 14

11 Only K is intracellular

Question 15

Dermatomyositis compared to polymyo?

Answer 15

Dermatomyositis with malignancy(both with intersititial lung diseae)

Question 16

Presentation of Strep pyo diseases do not have to be _most likely exclusive: RPGN vrs rheumatic disease

Answer 16

10. Presentation of Strep pyo diseases do not have to be concurrent most likely exclusive: RPGN vrs rheumatic disease

Question 17

anti _= anti-TRNA synthetase

Answer 17

anti-smooth muscle/ anti mitochondrial = autoimmune hepatitis/ PBColangitis,
anti jo= anti-TRNA synthetase

Question 18

ant. cruciate sticks to _ of femur
menisci does?
pec anserine(gts):

Answer 18

5. ant. cruciate sticks to ant & lat of femur pca is post & medial
   menisci is shock absorber
   pec anserine(gts): sat, semi tend, gracialis

Question 19

WHat does not change? in sacromere

Answer 19

Muscle: HI = thick/thin change A= doesn’t change

Question 20

Cutaneous small vessel vasculitis: leukocytoclastic(fragmented ) + lower leg nonblanching _ due to

Urticaria: transient, raised, _ due to meds; type 3 hypersensitivty

Answer 20

Cutaneous small vessel vasculitis:leukocytoclastic(gragmented neutrophils) + lower leg nonblanching purpura due to medications
Urticaria: transient, riased, blanchable due to meds; type 3 hypersensitivty

Question 21

_ = bacitran

Answer 21

PYR = bacitran

Question 22

10. Greater sciatic and sacro spine in sacrium are _

spinal stenosis is _dependent symptoms

Answer 22

10. Greater sciatic and sacro spine in sacrium are above

spinal stenosis is posture dependent symptoms

Question 23

Methotrexate(2l /hydroxychloroquine( _)/ minocycline ( _) cause = adverse effects

Answer 23

Methotrexate(lung + liver) /hydroxychloroquine( eye)/ minocycline ( dermatitis) cause = adverse effects

Question 24

Leukocyte adhesion deficieny due to lack of CD_

Answer 24

Leukocyte adhesion deficieny due to lack of CD18

Question 25

golgi tendon organ vrs muscle spindle system ?

Answer 25

golgi tendon organ vrs muscle spindle system regulate force/ lenght

Question 26

PPI's lansoprazole can cause _, _ infect | colchicine adverse effects: _ upset

Answer 26

diltiazem, Escitalopram PPI's lansoprazole can cause osteoporosis colchicine adverse effects: GI upset(diarrhea)

Question 27

Acne presents as ? | _ used is a know cause in atlethes

Answer 27

Acne presents as comedomal eruptions; anabolic steroid used is a know cause in atlethes

Question 28

Acne is inflammatory disorder of _ follicles with _keratinization of follicles->sebaceous gland _>_sebum secretion->_ by propion bacteria

Answer 28

Acne is inflammatory disorder of pilosebaceous follicles with hyperkeratinization of follicles->sebaceous gland enlargement>increased sebum secretion->colonization by propion bacteria

Question 29

treatment for psoriasis: topical _ & vit _ which inhib cell proliferation & stimulate differentiation

Answer 29

treatment for psoriasis: topical coticosteriods & vit D which inhib cell proliferation & stimulate differentiation

Question 30

compound nevi is in both _ so _ but not melanoma

Answer 30

compound nevi is in both epidermis & dermis so invasive but not melanoma

Question 31

acne risk factors: _(steroid type) pilosebaceous glands obstruction by oil based products, _irritation of follicules, _ paticipation

Answer 31

acne risk factors: androgens, pilosebaceous glands obstruction by oil based products, mechanical irritation of follicules, sports paticipation

Question 32

Actinic keratosis different from psoriasis on picture how?

Answer 32

scaly erythematous lesions with keratinocyte atypia, hyperkeratosis and parakeratosis with sand-paper like texture vrs thick white silvery scale

Question 33

Vitiligo is due to _of epidermal melanocytes, looks like?

Answer 33

Vitiligo is due to loss of epidermal melanocytes, looks like?

Question 34

How does sports participation trigger acne?

Answer 34

How does sports participation trigger acne: via used of tight-fitting clothing and protective gear

Question 35

Scabies: _ infection with excoriations and burrows _; presents with impaired _-mediated immunity; treat with _ or ivermectin

Answer 35

Scabies: mite infection with excoriations and burrows rash; presents with impaired cell-mediated immunity; treat with permethrin or ivermectin

Question 36

Foreign bodies elicit _ response.

Answer 36

Foreign bodies elicit granulomatous response.

Question 37

Supracondylar fractures may damages 3 thing under what conditions? lateral/medial displacement of proximal fracture seg?

Answer 37

Supracondylar fractures may damages 3 thing under what conditions? lateral/medial displacement of proximal fracture seg? Radial nerve/median nerve & brachial artery

Question 38

Another name for flexure retinaculum?

Answer 38

Another name for flexure retinaculum? Transverse carpal ligament

Question 39

Osteomyelitis? Bone infection. Most common bacteria 3 (child, sickle cell, pot, diabetes, impaired mobility, surgery)?

Answer 39

Osteomyelitis? Bone infection. Most common bacteria (child, sickle cell, pot, diabetes, impaired mobility, surgery)? staph ->strep, salmonella

Question 40

Direct inguinal due to weakness of what ? In what triangle? Borders

Answer 40

Direct inguinal due to weakness of what ? In what triangle? Borders Transversalis fascia, hasselbach, rectus abdominus& epigastric vessels( med & lat)

Question 41

MM on BM aspirate? | >_Plasma cell with _nuclear paleness(golgi) and clockface

Answer 41

MM on BM aspirate? | >10% Plasma cell with perinuclear palenss(golgi) and clockface

Question 42

Psoa is where?

Answer 42

Psoa is here? Psoas is at the veterbra, illacus is at the illac crest.