MSK oncology Flashcards Preview

MSK > MSK oncology > Flashcards

Flashcards in MSK oncology Deck (35):
1

A ______ is a malignant tumor of mesenchymal cell origin

sarcoma

2

A ____ is a benign tumor of the lipocyte cell line

lipoma

3

Most patients with soft tissue sarcomas are candidates for _______ surgery

limb salvage, goal to avoid amputation

4

A ______ is a malignant tumor derived from lipoblasts

liposarcoma

5

A _______ is a malignant tumor derived from the fibrous cell line and tend to be very aggressive

fibrosarcoma

6

The method of metastasis for most soft tissue tumors is _______.

hematogenous

7

__________ is the most common soft tissue sarcoma in children

rhabdomyosarcoma

8

How is rhabdomyosarcoma treated?

excision, radiation, chemotherapy

9

A _______ is a mass in the area of joints, but is not derived from the synovial lining of joints

synovial sarcoma

10

In adults, the most common malignant bone tumor is _______

multiple myeloma

11

A ______ is a bone lesion that develops near a growth plate in children

unicameral bone cyst

12

Describe the radiographic appearance of a unicameral bone cyst

well circumscribed lytic lesion, usually in calcaneous

13

What treatments are used for unicameral bone cysts?

bone graft
injection
cryotherapy

14

_______ is a hamartoma of bone, in which bone is laid down on fibrous stroma rather than by rimming osteoblasts

fibrous dysplasia

15

What are the three features of Albright's syndrome?

precocious puberty
cafe au lait spots
fibrous dysplasia

16

________ is a tumor that produces osteoid from malignant cells

osteogenic sarcoma

17

Describe the radiographic appearance of osteogenic sarcoma

sunburst appearance

18

What treatments are used for osteogenic sarcoma?

chemotherapy and surgery
relatively good overall survival but poorer prognosis if osteogenic sarcoma is secondary to anotehr process

19

If a patient with osteogenic sarcoma fails chemotherapy, it is usually due to development of distant disease, usually in the ______

lungs

20

In very young patients with osteogenic sarcoma, ______ is still the treatment of choice

amputation

21

_______ is a primitive mesenchymal sarcoma

Ewing's sarcoma

22

Describe pathologic features of Ewing's sarcoma

sheets of small round blue cells that stain positive for glycogen
pathology often similar to lymphomas, use cell markers to differentiate

23

Describe pathologic features of Ewing's sarcoma

sheets of small round blue cells that stain positive for glycogen
pathology often similar to lymphomas, use cell markers to differentiate

24

How is Ewing's sarcoma treated?

- chemotherapy + surgery in expendable bones
- radiation preferred in bones that have a large amount of growth remaining
- pelvis: chemo, surgery, radiation

25

Multiple myeloma is a ______ cell tumor of the bone marrow

plasma

26

The main treatment for multiple myeloma is _____

chemotherapy, sometimes radiation for small lytic lesions
systemic disease so no role for surgery

27

Bone scans in multiple myeloma are very "cold" because there is minimal _______ stimulation

osteoblastic

28

Most patients who have died of carcinomas show _________ at autopsy

metastatic bone disease

29

What are the most common bony sites of cancer metastasis?

spine, pelvis, femur, humerus

30

For cancers that commonly metastasize to bone, state whether they are blastic or lytic

breast: blastic or lytic
lung: lytic
prostate: blastic
kidney: lytic

31

_____ is successful in controlling metastatic bone lesions that are small and minimally painful

radiation

32

Current or imminent pathologic fractures in metastatic bone disease are treated with _____

surgical fixation

33

Achondroplasia involves an autosomal dominant genetic defect in ______

FGFR3
affects cartilage development

34

Osteogenesis imperfecta is due to an autosomal dominant or sporadic deficiency of _______

type 1 collagen

35

Name a physical exam finding that is characteristic of osteogenesis imperfecta

blue-grey sclera