Mucosal Immunity Flashcards Preview

Gastrointestinal > Mucosal Immunity > Flashcards

Flashcards in Mucosal Immunity Deck (19):
1

Where are the 5 main sites of lymphoid tissue in the GI tract?

Adenoid
Tonsils
Appendix
Peyer's Patch
Large intestine

2

Why does the GI tract need such a good immune response?

Vulnerable and fragile and is in constant contact with foreign pathogens

3

What are the 5 types of cells that prevent the bacteria in the gut interacting with the lamina propria of the gut wall and therefore entering the blood?

Enteroabsorptive cells
Goblet cells
Neuroendocrine cells
Paneth cells
Microfold Cells

4

What is the difference between the small and large intestine?

Small Intestine has
Villi
Crypts
Goblet cells
Paneth cells

Large intestine has
NO villi
Crypts
More goblet cells
NO Paneth cells
Higher bacterial load

5

What is the role of Paneth cells in the gut?

They release antimicrobial peptides

6

Where are immune cells found in the gut?

Peyer's patches and lamina propria

7

The colon has less immune-linked cells than the small intestine, how does it protect itself?

Double mucous layer, innermost layer is sterile

8

Natural Killer cells are more common in the small or large intestine?

Large

9

What produces antimicrobial peptides in the large intestine?

Enterocytes

10

How does the gut prevent infection

It captures the antigen
Initiates a local immune response
Carries out effector functions to clear infections

11

Which cells are the main cells in the enteric immune response?

Intestinal epithelial associated - innate immunity, antigen capture and effector function
Peyer’s patches and lymphoid follicles- antigen capture and initiation
Lamina propria- effector cells

12

What is the role of organised lymphoid tissue in the gut?

Initiation of immune response via drainage to mesenteric lymph nodes

13

What is another name for the lymphoid tissue of the GI tract?

GALT
Gut-associated lymphoid tissue

14

What is the genetic susceptibility of Coeliac disease

HLADQ2/HLADQ8

15

What can coeliac disease damage in the gut?

Villi - Loss of villi and atrophy in the villi reduces absorption
Scalloping in the intestine

16

What is the main diagnostic test for coeliac disease?

Biopsy

17

What is the serology test for coeliac disease?

Anti-tissue transglutaminase autoantibodies

IgA Anti-TTG

18

Lack of compliance for coeliac disease can cause...

Recurrent symptoms
Weight loss
Cancer

19

How does the enteric immune system and microbiota cause IBD?

IBD is thought to be caused by an alteration in the bacteria of the gut and a change in the way the immune system responds to harmless bacteria (causing an immune response and inflammation when it is not needed)