Mucosal immunity Flashcards Preview

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Flashcards in Mucosal immunity Deck (18):
1

immunoregulatory environment of the gut mucosa =__
is maintained by _+_

active downregulation of immune response - tolerance
inhibitory macrophages and tolerisng dendritic cells

2

Epithelial layer over Peyer's patch =
function=

M cells (microruffle cells)
large SA for taking in antigens by endo and phagocytosis to be picked up by dendritic cells below and then > T cells below that

3

T cells enter peyer's patches via ___ directed by __+__
are activated and then go to ___>_>_ (they express __+___ and so bind to __ on the mucosal endothelium)

bloodstream
CCR7 and L-selectin receptors
lymphatics>thoracic duct>blood
α4:β7 integrin and CCR9
MadCAM1

4

intraepithelial immune cells =

dendrites and CB8+ T cells

5

lamina propria immune cells in the gut =

CD4+ Ts
macros
mast cells
IgA
dendritic cells
plasma cells

6

humoral response in the intestines composition of Igs =

80% dimeric IgA, 15% IgM, 5% IgG

7

systemic humoral response composition of Igs =

reverse of intestinal
80% IgG, 15% IgM, 5% monomeric IgA

8

If virus infects gut epithelial cell __ presents it to T cells and causes apop by __

MHC-I
perforin/granzyme and Fas dependant pathway

9

If gut epithelial cell is stressed eg. Coeliacs they express ___ and bind to __ on T cells = apop by __

MIC-A+B
NKG2D
perforin/granzyme

10

Hyporesponsiveness in the gut mucosa is maintained by __+__

regulatory T cells
commensal bacteria

11

__ deficiency may give false negative Coeliac's test

Selective IgA immunodeficiency

12

Chronic granulomatous diseas (CGD) causes __/__ granulomas present as _+_+_+_
= no __ cells

S. aureus/ inflammatory
pneumonia, liver/ perianal/skin abscesses
no B cells

13

SCID is a T+/B cell deficiency
manifests as:
GI infectious agents =

T+B
oral candidiasis/chronic dirrhoea / interstitial pneumonitis
CMV/EBV/HIV/rotavirus

14

Coeliac's is a type __ hypersensitivity reaction
__ cell mediated
genetic susceptibility in ___+__

4
T
HLA-DQ2 + 8

15

Golden standard for diagnosis of Coeliac's =

biopsy

16

Test used to monitor dietary compliance in coeliac's

serology of auto Igs

17

4 mediators in Crohn's =

Th1 CD4+
γ inteferon
IL-12
TNF-α

18

4 mediators in UC =

Th1 and 2
NKT cells
I-13