Multiple myeloma Flashcards by Fu Chuen

What might you see in the blood film of a patient with multiple myeloma?

Rouleaux formation

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What are the features of multiple myeloma?

C alcium (high)
R enal impairment
A naemia
B one pain

Recurrent infections

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What is the cell type affected in multiple myeloma?

Plasma cells

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What is the diagnostic test for multiple myeloma?

Serum electrophoresis - M spike
Urine electrophoresis - Bence Jones
Bone marrow biopsy and aspiration

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What sort of protein in the urine in multiple myeloma?

Bence Jones Protein (Immunoglobulin light chain)

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What blood tests for suspected multiple myeloma and why?

Calcium and albumin levels - high calcium in multiple myeloma
Urea + Electrolytes - renal impairment in multiple myeloma
FBC - look for anaemia
Immunoglobulin panel - raised Ig light chains (could be kappa)

Urinalysis - looking for casts

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Give 3 complications of multiple myeloma?

Amyloidosis
Pathological fractures
Hypercalcaemia
Spinal cord compression

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Treatment for multiple myeloma?

Analgesia - for pain
IV fluids - rehydration and hypercalcaemia
IV Abx
Chemotherapy 
Stem cell transplant

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Multiple myeloma Flashcards

(8 cards)