Flashcards in Multiple myeloma Deck (10):
what are the 4 features of multiple myeloma?
1. BONE PAIN- Lytic lesions, think pathological fractures
2. ANAEMIA- normocytic
4. RENAL FAILURE- light chains aggregate and damage tubules in nephron
- think CRAB
what is multiple myeloma?
One particular plasma cell proliferates in an uncontrolled manner, leading to one specific type of Ig being produced
why do we get anaemia?
Plasma cells accumulate in the bone marrow causing anaemia (impaired production of normal blood cells)
why do we get renal injury?
accumulation of abnormal light chains (paraproteins) damages the renal tubules
what are paraproteins?
abnormal light chains
what are some complications of symptomatic multiple myeloma?
end stage organ failure e.g. kidney
immunosuppression (+ worse due to chemotherapy)
what are the Ig commonly found in Multiple myeloma?
IgG (2/3) and IgA (1/3)
how would we diagnose multiple myeloma?
• Protein electrophoresis
• Bone marrow biopsy
• Blood film
• U and E
Skeletal Xray looking for lytic lesions
what type of anaemia is it?