Flashcards in Multiple sclerosis Deck (15)
MS - 8 drugs
Interferon beta-1a (natalizumab)
Interferon beta-1b - MOA
Increases cytotoxicity of NK cells and increases the phagocytic activity of macrophages.
Reduces the amount of interferon-γ secreted by activated lymphocytes
Interferon beta-1b - adverse effects
Chills, diarrhea, fever, headache, hypertension, myalgia, pain, vomiting
Interferon beta-1b - interactions
Increases serum levels of zidovudine
Interferon beta-1a - MOA
Blocks the molecular pathway involving cell adhesion that draws lymphocytes into the CNS
Natalizumab - indications
Relapsing forms of MS
Mitoxantrone - MOA
Suppress T cells, B cells and macrophages that attack myelin sheath
Glatiramer acetate - MOA
Synthetic protein that mimics myelin protein structure. Block myelin-damaging T cells by acting as myelin decoy.
Dalfampridine - MOA
Block potassium channels and enhances conduction in damaged nerves
Fingolimod - MOA
Block egress of lymphocytes from lymph nodes, reducing the number of lymphocytes in peripheral blood.
Fingolimod - indications
Relapsing form of MS
Steroids - indications in MS
Which steroid is often used in MS exacerbations?
Prednisone (oral for mild cases, and parenterally in high doses for severe cases)
Steroids - adverse effects (MS)
Aggravation of DM, GI bleeding, mood changes, pancreatitis, seizures.