Multiple sclerosis Flashcards Preview

24 Neurodegenerative diseases > Multiple sclerosis > Flashcards

Flashcards in Multiple sclerosis Deck (15)
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1

MS - 8 drugs

Interferon beta-1b
Interferon beta-1a (natalizumab)
Mitozantrone
Glatiramer acetate
Dalfampridine
Fingolimod
Steroids
Baclofen

2

Interferon beta-1b - MOA

Increases cytotoxicity of NK cells and increases the phagocytic activity of macrophages.
Reduces the amount of interferon-γ secreted by activated lymphocytes

3

Interferon beta-1b - adverse effects

Chills, diarrhea, fever, headache, hypertension, myalgia, pain, vomiting

4

Interferon beta-1b - interactions

Increases serum levels of zidovudine

5

Interferon beta-1a - MOA

Blocks the molecular pathway involving cell adhesion that draws lymphocytes into the CNS

6

Natalizumab - indications

Relapsing forms of MS

7

Mitoxantrone - MOA

Antineoplastic agent.
Suppress T cells, B cells and macrophages that attack myelin sheath

8

Glatiramer acetate - MOA

Synthetic protein that mimics myelin protein structure. Block myelin-damaging T cells by acting as myelin decoy.

9

Dalfampridine - MOA

Block potassium channels and enhances conduction in damaged nerves

10

Fingolimod - MOA

Block egress of lymphocytes from lymph nodes, reducing the number of lymphocytes in peripheral blood.

11

Fingolimod - indications

Relapsing form of MS

12

Steroids - indications in MS

Acute exacerbations

13

Which steroid is often used in MS exacerbations?

Prednisone (oral for mild cases, and parenterally in high doses for severe cases)

14

Steroids - adverse effects (MS)

Aggravation of DM, GI bleeding, mood changes, pancreatitis, seizures.

15

Steroids - interactions (MS)

Barbiturates, carbamazepine, phenytoin and rifampin decrease serum levels