Flashcards in Multiple Sclerosis and other inflammatory CNS diseases Deck (26):
What is Multiple Sclerosis?
An inflammatory demyelinating disorder of the CNS
What does MS usually present?
30's and 40's
What are some clinical features of MS?
LR urinary tract dysfunction
Cerebellar and brain stem features
What are the Pyramidal dysfunction?
Extensors of upper limbs
Flexors of lower limbs
What are the Sensory Symptoms?
Dorsal column loss (Proprioception and vibration)
What are the cerebellar dysfunctions?
Diplopia is caused by problems with which cranial nerve?
Facial weakness is caused by a problem with which cranial nerve?
What is Internuclear Ophthamoplegia?
Medial Longitudinal fasciculus
Distortion of binocular vision
Failure of adduction (diplopia)
Nystagmus in abducting eye
What drug can help with sleepiness?
What drug can help with fatigue?
What is the criteria for diagnosing MS?
At least 2 episodes of demyleniation
Dissemination in time and place
What tests are used to diagnose MS?
What blood tests are useful in diagnosing MS?
PV, FBC, CRP
Renal liver bone profile
Auto antibody screen
Borellia, HIV, syphilis serology
B12 and folate
What is the treatment for a mild acute exacerbation of MS?
What is the treatment for a moderate acute exacerbation of MS?
What is the treatment for a severe acute exacerbation of MS?
What are potential treatments for spasticity?
Give an example of an anti-convulsant?
Give an example of an anti-depressant?
What drugs can help with incontinence?
Anti-cholinergics e.g. Oxybutynin
What are first line drugs for MS?
Interferon Beta (Avonex, Rebif, Betaseron, Extavia
Glitiramer acetate (Capaxone)
What are second line drugs for MS?
Monoclonal antibody - Tysabri, Lemtrada
What is a 3rd line drug for MS?
What virus is positive with PML associated with TYSABRI?