Muscarinic Antagonists: Side Effects Flashcards Preview

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Flashcards in Muscarinic Antagonists: Side Effects Deck (30)
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1

Compared to atropine, glycopyrrolate is MORE likely to cause:

Study on!!!

2

The three commonly used muscarinic antagonists (aka Anticholinergics) are:

 

Atropine

Scopolamine

Glycopyrrolate

3

You should be able to compare the differences between the three commonly used muscarinic antagonists (aka Anticholinergics)

 

True

4

Which muscarinic antagonists (aka Anticholinergics) increases heart rate the most?

 

Atropine > Glycopyrrolate > Scopolamlne

5

Which muscarinic antagonists (aka Anticholinergics) causes Smooth muscle relaxation the most?

 

(Atropine = Glycopyrrolate) > Scopolamlne

6

Which muscarinic antagonists (aka Anticholinergics) causes Sedation the most?

 

Scopolamlne > Atropine

7

Which muscarinic antagonist (aka Anticholinergic) is a better Antisialagogue and therefore is more likely to cause "dry mouth" otherwise known as Xerostomia?

 

Scopolamlne > Glycopyrrolate > Atropine

8

Which muscarinic antagonists (aka Anticholinergics) is more likely to cause Mydriasis Cycloplegia?

 

Scopolamlne > Atropine

9

Which muscarinic antagonist (aka Anticholinergic) is more likely to prevent motion-induced nausea

 

Scopolamlne > Atropine

 

10

Which muscarinic antagonists (aka Anticholinergics) decrease gastric H + secretion

 

Atropine = Glycopyrrolate = Scopolamlne

11

Atropine and Scopolamine are

A. naturally occurring tertiary amines

B. quaternary ammonium derivatives

"naturally occurring tertiary amines"

12

Atropine and scopolamine are naturally occurring tertiary amines. They are

A. lipophilic

B. hydrophilic

Lipophilic

13

Atropine and Scopolamine are naturally occurring tertiary amines. Because they are lipophilic, they ----- lipid membranes including the BBB, GI tract, and placenta

"easily cross"

14

Glycopyrrolate is a

A. naturally occurring tertiary amine

B. quaternary ammonium derivative

"quaternary ammonium derivative"

15

Glycopyrrolate is different. As a quaternary ammonium derivative, it is

A. unionized

B. ionized

"ionized"

16

Glycopyrrolate is different. As a quaternary ammonium derivative, it is ionized. This ----- its ability to cross cell membranes

"limits"

17

Glycopyrrolate is different. As a quaternary ammonium derivative, it is ionized. This limits its ability to cross cell membranes. Therefore, it ----- CNS activity or crosses the placenta

"does not possess"

18

Small doses of atropine can cause a paradoxical -----.

Bradycardia

19

Small doses of Atropine can cause Paradoxical Bradycardia. This is probably due to the inhibition of the ----- receptor on vagal nerve endings

Presynaptic M1 receptor

20

Small doses of Atropine can cause Paradoxical Bradycardia. This is probably due to the inhibition of the presynaptic M1 receptor on vagal nerve endings. This receptor's job is to ----- Ach release via a negative feedback loop

"reduce"

21

Small doses of atropine can cause paradoxical bradycardia. This is probably due to the inhibition of the presynaptic M1 receptor on vagal nerve endings. This receptor's job is to reduce Ach release via a negative feedback loop. Blockade of the presynaptic M1 receptor ----- this negative feedback loop
 

"turns off"

22

Small doses of atropine can cause paradoxical bradycardia. This is probably due to the inhibition of the presynaptic M1 receptor on vagal nerve endings. This receptor's job is to reduce Ach release via a negative feedback loop. Blockade of the presynaptic M1 receptor "turns off" this negative feedback loop and allows for continued Ach release which causes -----.

Bradycardia

23

Muscarinic antagonists do not affect the ----- of the patient with a previous heart transplant

Heart rate

24

Muscarinic antagonists do not affect the heart rate of the patient with a previous heart transplant. Even so, these patients will still experience other ----- effects from AchE inhibitors, so they should receive a muscarinic antagonist with an AchE inhibitor

 

Cholinergic effects

(DUMBBELLS)

25

Muscarinic antagonists do not affect the heart rate of the patient with a previous heart transplant. Even so, these patients will still experience other Cholinergic effects from AchE inhibitors, so they should still receive a ----- with an AchE inhibitor

Muscarinic antagonist

(aka Anticholinergic)

26

Compared to atropine, glycopyrrolate is MORE likely to cause:

Xerostomia

27

Compared to atropine, ----- is more likely to cause xerostomia (dry mouth). This makes it particularly useful for awake fiberoptic intubation as well as oral surgery

Glycopyrrolate

28

Glycopyrrolate is a quaternary ammonium and this prevents it from ----- the blood-brain barrier

"crossing"

29

Atropine is a tertiary ammonium (it ----- the BBB), so it produces sedation and mydriasis. It's also associated with a more significant tachycardia

"crosses"

30

Reference:

 

Flood. Stoelting's Pharmacology & Physiology in Anesthetic Practice. 5th ed. 2075 . p. 7 96.