myeloma

Question 1

what is multiple myeloma

Answer 1

haematological malignancy characterised by plasma cell proliferation

Question 2

features of myeloma

Answer 2

CRABBI:
- hyperCalcaemia
- Renal: light chain deposition within renal tubules, dehydration and increased thirst, amyloidosis, nephrocalcinosis, nephrolithiasis
- Anaemia
- Bleeding: thrombocytopenia
- Bones: pathological fractures
- Infection

Question 3

investigations for myeloma

Answer 3

bloods: anaemia, peripheral blood film shows rouleaux formation, renal failure, hypercalcaemia
protein electrophoresis: raised monoclonal IgA/IgG, bence jones proteins
bone marrow: raised plasma cells
whole body MRI
x-ray: rain drop skull